2018年11月15日 · Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated necroptosis. We found that RIPK1 and...

Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many stimuli, including growth factors, inflammatory cytokines, and a wide spectrum of cellular stresses.

2024年6月28日 · JNK signaling can be activated by environmental stresses (e.g., UV radiation, oxidative damage) and pro-inflammatory factors (e.g., TNFs), and plays critical roles in many cellular events...

2005年1月1日 · In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK...

2021年12月1日 · We report that JNK has a dual role in the TNF-stimulated death of fibroblasts. JNK can suppress TNF-stimulated apoptosis, but can also potentiate TNF-stimulated necrosis. The increased necrosis is mediated, in part, by a requirement of JNK for TNF-induced production of cytotoxic reactive oxygen species (ROS). Results

These results demonstrate a causal role for JNK and caspases in TNF+CHX-induced apoptosis of Huh7 human hepatoma cells. Therefore, strategies aimed at enhancing both pathways should provide a profitable basis to overcome the resistance …

Our findings show that: (i) TNF-RII is able to activate two members of the MAP kinase family: extracellular regulated kinase (ERK) and c-jun N-terminal kinase (JNK); (ii) TRAF2, a molecule that binds TNF-RII and associates indirectly with TNF-RI, is sufficient to activate JNK upon overexpression; (iii) dominant-negative TRAF2 blocks TNF alpha ...

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun …

2004年2月20日 · Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF. Tumor necrosis factor-α (TNF) plays a pivotal role in orchestrating innate inflammatory responses in vertebrates.

2012年1月18日 · 这项研究揭示了一种新的分子机制，即通过Miz1抑制TNF-α-JNK的激活可以通过自身特殊位点的遍在蛋白化和降解来进行脱阻抑。 林安宁研究组主要从事癌症信号转导网络与基因调控的分子机理方面的研究，实验室的工作主要是利用c-Jun N-terminal protein kinase (JNK)和IkB kinase (IKK)/NF-kappaB等分子探针来研究决定信号转导网络的可塑性和特异性的分子机制，试图理解信号转导网络调控的异常怎样导致人类疾病和癌症。 去年这一研究组还在《Molecular …