c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser -63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock.

2014年4月17日 · JNKs are sensors of stress, eliciting transcriptional responses in the nucleus and intrinsic death pathway responses in the cytosol, which communicate a strong pro-apoptotic signal. Inhibitors...

2016年7月27日 · Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. Many of these proteins are direct substrates of the JNKs. We analyzed almost 100 of these target proteins in detail within a framework of their classification based on their regulation by JNKs.

2003年7月1日 · JNK's represent attractive targets for immunomodulatory drug development. Neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases, and stroke, share synaptic...

2024年8月1日 · C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and cancer progression.

2020年1月1日 · JNKs are serine/threonine kinases phosphorylating several substrates such as c-Jun and activating transcription factor 2. There are three closely related genes, JNK1, JNK2, and JNK3, encoding 10 splice variants of JNKs [3].

2021年9月6日 · c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation.

2022年3月10日 · c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, are encoded by three genes: jnk1, jnk2, and jnk3. JNKs are involved in the pathogenesis and development of many diseases, such as neurodegenerative diseases, inflammation, and cancers. Therefore, JNKs have become important therapeutic targets.

2024年10月7日 · JNK signaling, an integral component of the Mitogen-Activated Protein Kinase (MAPK) pathways, plays crucial roles in various cellular processes. Understanding this …

2018年6月21日 · JNKs are serine/threonine kinases belonging to the evolutionary conserved mitogen-activated protein kinase (MAPK) family. JNKs are also known as stress-activated protein kinases because of their...