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c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser -63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock.

Paris Blohm & Taylr Renee - Left Behinds (JNNK Remix) by JNNK published on 2015-02-02T20:43:30Z

JNK，（c-Jun氨基末端激酶，c-Jun N-terminal kinase）又被称为应激活化蛋白激酶 (stress-activated protein kinase, SAPK)，是哺乳类细胞中MAPK（mitogen-activated protein kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。 和其他 MAPK 一样，膜近端激酶是一个 MAPKKK（通常为 MEKK1–4），或是混合性谱系激酶（MLK）中一员，能磷酸化并激活 MKK4 (SEK) 或 MKK7（即 SAPK/JNK 激酶）。 此外， MKK4/7 能由生发中心激酶 (GCK) 家族成员以独立于 …

Jannik. Mr. "mal so, mal so"

2016年7月27日 · Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. Many of these proteins are direct substrates of the JNKs. We analyzed almost 100 of these target proteins in detail within a framework of their classification based on their regulation by JNKs.

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders.

2014年4月17日 · JUN amino-terminal kinases (JNKs) are dominant regulators of protein phosphorylation in the nervous system. JNKs serve critical functions in developing brain, being required...

2008年10月20日 · JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of...