2025年1月24日 · These mice carry a transgene encoding human tau with four microtubule-binding repeat domains and no N-terminal inserts (4R/0N). The transgene contains the P301L …

JNPL3 Mice. JNPL3 mice were the first mouse model established to carry a MAPT mutation (Lewis et al., 2000). They express human 0N4R tau with the P301L mutation, driven by the …

2000年9月1日 · We analysed sarkosyl-insoluble tau from brains and spinal cords of JNPL3 mice at progressive ages, littermate controls, JN4 and JN25 (WT4R) mice by western blot using …

2023年8月9日 · The P301L mutation makes tau prone to aggregation; therefore, JNPL3 mice present a more challenging target than mouse models of human tau without mutations. JNPL3 …

2001年8月24日 · Hemizygous JNPL3 mice develop progressive motor and behavioral abnormalities with robust neurofibrillary pathology and neuronal loss in the spinal cord as early …

2024年10月5日 · A large fraction of neurons were hypoactive in JNPL3 mice. Treadmill running revealed that JNPL3 mice had less activated and more suppressed neurons compared to WT …

2001年8月24日 · JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 …

2023年8月9日 · JNPL3 mice present a more challenging target than mouse models of human tau without mutations. JNPL3 mice were treated from 3 to 7 months of age with Vehicle, 30 mg/kg …

2025年1月3日 · We observed neuronal hypoactivity in the motor cortex of 6-month-old JNPL3 mice, when the animals were at rest or running on a treadmill. Neuronal Ca 2+ activity …

In JNPL3 transgenic (Tg) mice, expression of human tau containing the most common FTDP-17 mutation (P301L) under the control of the mouse prion promoter resulted in motor …