Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...

Fos 家族和 Jun 家族相互作用形成同源或异源二聚体，称为 AP-1（activator protein-1，转录激活蛋白-1），是转录因子的典型代表。 Jun 蛋白家族包括 c-Jun、Jun-B、Jun-D。 两个家族的一级结构均具有一个保守的亮氨酸拉链（leucine zipper）结构：在 30 个拉链的氨基酸组成的 α 螺旋中，每 7 个氨基酸残基重复出现一个亮氨酸残基，N 端富含一个碱性氨基酸伸展，故又称碱性拉链（basic zipper，bZIP ），含有这一结构的蛋白质又称 bZIP 蛋白家族。 碱性区则是结合 DNA …

Jun蛋白和Fos蛋白组成的二聚体复合物AP-1是细胞核内重要的转录因子,细胞的外界刺激信号从上游的信号通路传递至AP-1,并激活AP-1的功能,进而调节其下游一系列基因启动子区域含有AP-1结合位点靶基因的转录表达,使细胞对外界刺激作出适应性的反应.本文综述了jun和 ...

2024年12月26日 · c-Fos蛋白在细胞内的作用主要是与c-Jun形成异二聚体，进而构成AP-1（Activator protein-1）复合物。AP-1复合物作为一种转录因子，能够与目标基因的启动子和增强子区域结合，从而调控下游基因的表达。

2001年4月30日 · Fos and Jun family proteins regulate the expression of a myriad of genes in a variety of tissues and cell types. This functional versatility emerges from their interactions with related bZIP...

Using a novel scoring metric, we uncovered that transcriptional activation of JUN/FOS genes of the Activating Protein‐1 (AP‐1) complex—particularly the upregulation of Jun, Fos, and Fosb genes—is the most conserved aging signature across the two mouse strains, diverse immune tissues, and cell types.

The fos and jun proto-oncogenes are members of the set of genes known as cellular immediate-early genes. Their expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. They encode DNA binding pr …

2024年12月25日 · JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Breast Cancer and Hematologic Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

Fos/Jun 复合物与特定的对称 DNA 识别序列 3-9（称为 TRE）结合，从而刺激相应基因 3,9-12 的转录。 在这里，我们表明 Fos 中的两个不同区域是形成 Fos/Jun/TRE 复合物所必需的。

Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied in mouse development as well as in the whole organism through conventional transgenic approaches, but also by gene …