JNK，（c-Jun氨基末端激酶，c-Jun N-terminal kinase）又被称为应激活化蛋白激酶(stress-activated protein kinase, SAPK)，是哺乳类细胞中MAPK（mitogen-activated protein kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。

c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser -63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock.

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions. The JNK family of serine/threonine protein kinases comprises three isoforms (JNK1, JNK2 and JNK3).

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。

2022年10月17日 · In this study, we show that c-JUN N-terminal multisite phosphorylation by JNK occurs with a range of rates, leading to intrinsic temporal phosphorylation states, both in vitro and in vivo.

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation.

The regulation of c-Jun transcriptional activity by Jun N-terminal kinase (JNK) has become a paradigm for understanding how mitogen-activated protein (MAP) kinase signalling pathways elicit specific changes in gene transcription through selective phosphorylation of …

c-Jun N-末端激酶 (JNK) 是丝裂原活化蛋白激酶 (MAPK) 家族的成员，由三个基因编码：jnk1、jnk2和jnk3. JNK参与了许多疾病的发病机制和发展，例如神经退行性疾病、炎症和癌症。

Jun N-terminal kinase (JNK)的中文是不是就读作 c-Jun [si: d?u:n]氨基末端激酶？ 英文发音，其中的N是读该字母的发音还是应该发氨基amino读音？ JNK发音的时候，是要连在一起读成一个单词，还是应该单独发这3个字母的音？ 因为每次做PPT汇报的时候都会很纠结，一些英文的习惯读法不太了解，所以咨询一下大家，先谢过了！ Jun N-terminal kinase (JNK)的中文是不是就读作 …

This study analysed the antifibrotic effects of the selective c-Jun N-terminal kinase (JNK) inhibitor, CC-930, which recently entered first clinical trials as a novel antifibrotic approach.

2024年9月20日 · Aberrant activation of c-Jun N-terminal kinase 1 (JNK1) has been implicated in its pathogenesis. Through a combination of structure-based drug design and structure–activity relationship (SAR) optimization, a series of pyrimidine-2,4-diamine scaffold derivatives have been developed as potent JNK1 inhibitors.

JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that …

c-Jun N 末端激酶 (JNK) 有助于免疫信号传导，但它们在肠粘膜炎症期间的功能作用仍未明确。 使用遗传小鼠模型，我们描述了 JNK1 和 JNK2 在稳态和急性结肠炎期间的作用。

The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such …

c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF-κB, JAK/STAT, and other signaling molecules to exert a survival function.

2015年3月18日 · c-Jun N-末端激酶（JNK）是促丝裂原激活蛋白激酶家族成员，转导细胞外信号为细胞内反应。JNK信号通路主要被细胞因子和应激刺激激活，调节细胞迁移，参与细胞增殖、分化、炎症和程序性死亡。

2001年2月2日 · Recent studies have shown that the Jun N-terminal kinase (JNK) signaling pathway regulates multiple biological processes in lymphocytes. The JNK pathway is activated in response to a variety of extracellular stresses and mitogenic factors including T cell antigen receptor (TCR) ligation .

C-Jun N-Terminal Kinases (JNK) are stress-activated protein kinases that regulate the transcription factor AP-1, influencing the expression of genes involved in immune responses. They are targeted for drug development in chronic inflammatory diseases and have been linked to the development of diabetes, insulin resistance, and obesity.

Emerging evidence indicates that c-Jun N-terminal kinase (JNK) serves as a potential regulator within the intricate molecular clock governing aging-related processes. JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate β-galactosidase activity, and induce telomere shortening, thereby contributing to ...

2020年11月12日 · The c-Jun-N-terminal kinase (JNK) is a critical mediator involved in various physiological processes, such as immune responses, and the pathogenesis of various diseases, including autoimmune disorders.