JWH-018 (1-pentyl-3- (1-naphthoyl)indole, NA-PIMO[3] or AM-678) [4] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB 1 and CB 2 cannabinoid receptors, with some selectivity for CB 2.

2023年5月25日 · JWH-018 was identified as one of the primary psychoactive components present in Spice/K2 preparations. This study evaluated the short- and long-term consequences of exposure to JWH-018 during...

JWH-018 is a type of analgesic chemical from the naphthoylindole family that functions as a full agonist at both the CB1 and CB2 cannabinoid receptors. It was first synthesized by Dr. John W. Huffman and has been discovered in herbal smoking blends like Spice.

Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive “spice” products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT 2A/2C receptor function in the brain, an effect which might contribute to psychotic symptoms.

Today, the JWH series of cannabinoids are arguably the dominant cannabinoids detected in Spice (Carroll et al., 2012; Uchiyama et al., 2011a). JWH-018 (1-penthyl-3-(1-napthoyl)indole) was one of the first compounds to be abused and probably selected because the compound is easily synthesized and has high pharmacological activity ( Huffman, 2009 ...

In 2008, the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) detected unregulated, psychoactive synthetic cannabinoids (SCBs) in purportedly all-natural herbal incense products (often known as K2 or Spice) that were being covertly abused as marijuana substitutes.

1-Pentyl-3-(1-naphthoyl)indole (also called AM-678 and JWH-018) is a full agonist synthetic cannabinoid first synthesized by organic chemist John W. Huffman. It gained popularity in late 2008 when German chemists found it as a chemical within the popular synthetic cannabis blend Spice, which had been sold in numerous countries around the world ...

2017年9月5日 · Administration of JWH-018 (1.5, 2.5 and 5 mg/kg) increased seizure spikes dose-dependently. Pretreatment of mice with AM-251 (5 mg/kg), a cannabinoid receptor 1-selective antagonist, completely...

2014年8月1日 · Abuse of synthetic cannabinoids ('Spice') as an alternative to cannabis is increasing rapidly. Despite their widespread use, the risks of these products are unknown. Based upon the pharmacology of the primary constituents of Spice, JWH-018 and JWH-073, the synthetic cannabinoids pose a greater risk for substance use disorder than cannabis.

JWH-018 is a synthetic cannabinoid receptor selective agonist that has been studied for its pharmacological properties and potential therapeutic applications in neuroscience. You might find these chapters and articles relevant to this topic. Martin F. Casey, Alex F. Manini, in Novel Psychoactive Substances (Second Edition), 2022.