2022年9月19日 · Ambrosino P, Soldovieri MV, Di Zazzo E, et al. Activation of Kv7 potassium channels inhibits intracellular Ca (2+) increases triggered by TRPV1-mediated pain-inducing stimuli in F11 immortalized sensory neurons. 2019;20 (18):E4322. 8.

Among these, a growing body of evidence supports a role for the two‐pore domain potassium (K2P) family of K + channels. Here, we provide a concise review of the K2P channels, their role in pain biology and their potential as targets for novel analgesic agents.

2018年10月16日 · Among these, a growing body of evidence supports a role for the two-pore domain potassium (K2P) family of K + channels. Here, we provide a concise review of the K2P channels, their role in pain biology and their potential as targets for novel analgesic agents.

Given their importance in pain modulation, voltage-gated K channels (K) and 2-pore domain K channels (K2P) are potential targets for designing novel analgesic compounds. This review will focus on K2P channels, which are multimodal sensors that may have an important role in several pain disorders, including neuropathic pain and migraine.

Recent evidence points to a pivotal contribution of a variety of different potassium channels, including two-pore domain potassium (K2P) channels, in chronic pain processing. Expression of several different K2P channel subunits has been detected in nociceptive dorsal root ganglion neurons and trigem …

2016年1月20日 · 在整个审查过程中，钾离子通道在疼痛中的作用是显而易见的，这使它们成为创新镇痛药的潜在目标，根据通道的不同，其具有周围和/或中央作用。 显然，用已知或新颖的钾通道开放剂获得的一些初步结果表明，它们可能代表神经性疼痛或其他病理情况下的新型镇痛药。 2015年国际神经性疼痛大会的一个研讨会重点讨论了钾通道，以提出有关这些通道在疼痛调节中作用的新兴观点，并确定它们是否可以成为设计新型镇痛药的相关靶标。 特别引起了两种钾通 …

2022年3月16日 · The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion channels, TREK1, TREK2 and TRAAK from the TREK subfamily of the Two-Pore-Domain potassium (K 2P ) channels, are hyperpolarizing channels that render neurons ...

Recent findings: We now recognize that certain K+ channel subunits are directly gated to pain-relevant stimuli (Kv1.1, K2P) whereas others are specifically modulated by inflammatory processes (Kv7, BKCA, K2P). Genetic analyses illustrate that K+ channel gene variation can predict pain sensitivity (KCNS1, GIRKs), risk for persistent pain (KCNS1 ...

2012年3月5日 · The ability to sense mechanical, thermal, and chemical stimuli is critical to normal physiology and the perception of pain. Contact with noxious stimuli triggers a complex series of events that initiate innate protective mechanisms designed to minimize or avoid injury.

2014年11月26日 · Recent evidence points to a pivotal contribution of a variety of different potassium channels, including two-pore domain potassium (K2P) channels, in chronic pain processing. Expression of several different K2P channel subunits has been detected in nociceptive dorsal root ganglion neurons and trigeminal ganglion neurons, in particular, TREK1 ...