Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia (CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective imatinib-mesylate...

Does anyone have experience with the markers expressed on K562 cells? I have checked DSMZ and when I stain my cells with the markers stated that K562 should be positive for and run the profile...

2020年2月27日 · Flow cytometry of cell surface markers of K562 and K562-IR cells. CD45, CD33, CD65, CD146 hematologic marker expressions are reduced in K562-IR cells. CD44 and SSEA-4 have increased expression while no difference was observed in CD34 and CD38.

K-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research. Please fill out the form below to sign up for notification when the product becomes in stock. You were successfully signed up for notification.

K562实验特点在于以慢性髓性白血病细胞系为研究对象,探讨其侧群细胞的分选及与非侧群细胞表面标记的表达差异,以期为肿瘤干细胞的筛选鉴定提供依据。 K562 K562 流式细胞仪检测细胞株中存在侧群细胞,这群细胞数量少。 在侧群细胞亚群中CD34+、 说明细胞株侧群细胞亚群部分表面抗原标记和非侧群细胞亚群相比存在异质性。 背景:白血病侧群细胞表型的研究对于理解肿瘤细胞的异质性K562和起源、分子标记和靶向治疗等都有积极意义。 目的:鉴定人慢性粒细胞白血病细 …

This study concerns the analysis of the modulation of Chronic Myeloid Leukemia (CML) cell model K562 transcriptome following transfection with the tumor suppressor gene encoding for Protein ...

Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate. Further, K562 ...

2011年5月10日 · 结论:k562细胞的免疫学表型和形态学均表现出未分化细胞特征,因其具有多项分化潜 能,因此更适合进行细胞多向分化研究。 HL60的髓系祖细胞特性明显,适合进行粒系、单核系分化研究。

Chen TR. Modal karyotype of human leukemia cell line, K562 (ATCC CCL 243). Cancer Genet. Cytogenet. 17: 55-60, 1985. PubMed: 3857109 Wu SQ, et al. Extensive amplification of bcr/abl fusion genes clustered on three marker chromosomes in human leukemic cell line K-562. Leukemia 9: 858-862, 1995. PubMed: 7769849 备注： 1.

目的分离白血病K562细胞株中CD34+细胞群,并分析其生物学特征,为从干细胞角度治疗白血病提供实验依据.方法采用免疫磁性分选法分离K562细胞中CD34+细胞群,台盼蓝拒染法检测细胞活性;流式细胞术检测CD34+细胞比例及细胞周期;单细胞克隆培养检测CD34+细胞自我更新 ...