K562 xenograft refers to the transplantation of K562 cells into immunocompromised mice, which allows for the study of the growth and progression of K562-derived tumors in vivo. K562 xenograft models have been widely used in cancer research to evaluate the efficacy of potential therapeutic agents against leukemia.

The K562 xenograft model can be used to investigate the pivotal role of tissue inhibitors of metalloproteinases (TIMPs) for the treatment of leukemia. K562 xenograft models have also been used to study the molecular mechanisms underlying leukemia development and progression.

2014年5月9日 · We found that PMA treatment of K562 cells induced significant activity decline in complex IV, which correlated with the low O 2 consumption and might be a change by the cells in order to meet the metabolic characteristics of differentiated cells.

2014年5月9日 · Furthermore, we found that the level of the complex IV core subunit COX3 and mitochondrial transport-related proteins Tim9 and Tim10 were decreased during the differentiation of K562 cells induced by PMA, suggesting an important role of these factors in mitochondrial functional changes.

Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate.

2016年9月21日 · To test the ability of human memory-like NK cells to control leukemia in vivo, we engrafted K562-luc (luciferase-expressing) leukemia cells in NSG mice and adoptively transferred human IL-12, IL-15, and IL-18–preactivated or control NK cells into groups of NSG mice on day 4 .

K562 cells were the first human immortalised myelogenous leukemia cell line to be established. K562 cells are of the erythroleukemia type, and the cell line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis .

2010年9月3日 · We developed a simple experimental system to evaluate the ADCC activity in vivo. Human NK cells killed an NK-sensitive cell line, K562, in NOG mice. Human NK cells and Rituximab treatment prolonged the survival of NOG mice by ADCC.

Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate.

2019年6月15日 · This research was conducted to evaluate the cytotoxic effects induced by di- and triphenyltin (IV) (2-methoxyethyl) methyldithiocarbamate compounds against human erythroleukemic cell line (K562 cell) using MTT assay.