2023年3月2日 · Bioluminescence imaging is useful for non-invasively monitoring inflammatory reactions associated with disease progression, and since NF-κB is a pivotal transcription factor that alters expressions...

019995 B6.129P2- H2-K1 b-tm1Bpe H2-D1 b-tm1Bpe /DcrJ These double H2K b D b KO mice carry knockout alleles of the MHC class I genes and exhibit decreased susceptibility to viral infection, as well as enhanced motor learning.

2006年2月10日 · New mouse models are required to pinpoint the effects of alternative NF-κB signalling, such as mice permitting the conditional activation and inactivation of IKK1 or NIK, or the conditional ...

1998年10月13日 · We have generated mice deficient for the classical MHC class Ia molecules (K b and D b) by intercrossing mice defective in either K b (H-2K b −/−) or D b (H-2D b −/−) and screening for rare intra-H-2 recombinants.

2022年5月19日 · In this work we describe the generation and analysis of ROSA26 knock-in NF-κB reporter (KappaBle) mice containing a destabilized EGFP, which showed sensitive, dynamic, and faithful monitoring of...

2022年11月22日 · Rahman et al. present fluorescent knockin mice that track one or both of the canonical subunits of NF-κB. The power of these reporters is illustrated with several approaches that gain deeper insights into NF-κB biology. The mice enable diverse applications from single-molecule analyses to in situ identification of active inflammatory cells.

Toward our goal to define mechanisms through which NF-kappaB leads to the development of disease, we have developed transgenic mice that express luciferase under the control of NF-kappaB, enabling real-time in vivo imaging of NF-kappaB activity in intact animals.

2022年11月22日 · In vitro studies suggest that mapping the spatiotemporal complexity of nuclear factor κB (NF-κB) signaling is essential to understanding its function. The lack of tools to directly monitor NF-κB proteins in vivo has hindered such efforts. Here, we introduce reporter mice with the endogenous RelA (p6 …

2023年3月2日 · Bioluminescence imaging is useful for non-invasively monitoring inflammatory reactions associated with disease progression, and since NF-κB is a pivotal transcription factor that alters expressions of inflammatory genes, we generated novel NF-κB luciferase reporter (NF-κB-Luc) mice to understand the dynamics of inflammatory responses in ...

1997年11月15日 · Transgenic mice expressing chimeric human (alpha1 and alpha2 HLA-A11 domains) and murine (alpha3, transmembrane, and cytoplasmic H-2Kb domains) class I molecules were derived. These mice were used as a model system to study the immunogenicity of human CTL epitopes and also to examine the aspects of …