2023年11月1日 · Histone acetyltransferases (HATs) utilize acetyl-CoA as a coenzyme to catalyze the N-acetylation of lysine residues in histones H3 and H4.

2018年9月25日 · We identify 4 lysine butyrylation (Kbu) sites (H3K14, H4K12, H2BK42, and H2BK134) and 45 crotonylation (Kcr) sites on rice histones by mass spectrometry.

2016年4月21日 · We propose that at active gene TSSs, p300 (and possibly other HATs) randomly use acetyl- or butyryl-CoA to modify histone tails. HDACs and histone variants, also present at …

2025年1月9日 · Epigenetic effects of butyrate and propionate have been attributed to histone deacetylase (HDAC) inhibition and to the activation of histone acetyl transferases (HATs) 4, 5, …

2021年3月4日 · HATs are divided into three significant families by their sequence and structural features, such as Gcn5-related N-acetyltransferases (GNATs), the P300/CREB-binding protein …

2 天之前 · HATs 不仅调节组蛋白 Kcr，还控制许多非组蛋白 Kcr 修饰，影响关键的细胞通路。 例如，CBP 和 hMOF 强烈巴豆酰化非组蛋白 NPM1，PCAF 对其有中等程度的巴豆酰化活 …

Histone acetylation levels are co-regulated by HDACs (erasers) and HATs (writers). HATs are relatively distinct from each other. HDACs can be further classified as Class I, IIa, IIb, III, and IV.

2023年7月7日 · 到目前为止确定的新型蛋白质酰基化的“writer”和“eraser”都是之前定义的组蛋白乙酰基转移酶（HATs）和组蛋白去乙酰化酶（histone deacetylases, HDACs)。 既往研究表明 …

3 天之前 · Kcr writers. Crotonyltransferases, often called the "writers" of Kcr, play a key role in this modification [4, 20].With the well-characterized regulatory enzyme systems of acetylation in …

近日，来自美国North Carolina大学的 Ian J. Davis教授 团队，在 Cell 子刊 Cell Reports 上，发表了题为“HDAC inhibition results in widespread alteration of the histone acetylation landscape …