郭江涛课题组发文解析人源钾氯共转运蛋白KCC2,3,4的冷冻电镜结构
2020年12月15日 · 人类基因组共编码 2 个钠钾氯共转运蛋白（NKCC1 和 NKCC2）、1 个钠氯共转运蛋白（NCC）和 4 个钾氯共转运蛋白（KCC1-4）。 NKCC和NCC利用细胞膜两侧的Na+ …
解析人源钾氯共转运蛋白KCC2,3,4的冷冻电镜结构 - 网易
2020年12月14日 · 随着跨膜螺旋tm12的旋转和平移，n末端抑制肽与c末端之间的相互作用被破坏，使得n末端肽段从面向胞质的腔中解离，kcc被激活。 本研究解析了kcc家族完整的结构，发 …
King County Code - King County, Washington
Explore the laws and charter governing King County. All permanent or general laws are incorporated into and become a part of the King County Code. The contents of the code …
Cryo-EM structures of the full-length human KCC2 and KCC3 …
2020年11月16日 · The electroneutral K + -Cl − cotransporters (KCCs) play fundamental roles in trans-epithelial transport, cell volume regulation, and neuronal excitability. 1 The neuronal …
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target …
2023年9月13日 · Inhibiting WNK kinase or utilizing newly discovered KCC2 agonists has demonstrated KCC2 activation and seizure attenuation in animal models. This review …
Cell Res | 重大进展！西湖大学周强团队揭示全长人KCC2和KCC3结 …
2020年11月17日 · 电中性k + -cl-共转运蛋白（kcc）在跨上皮运输，细胞体积调节和神经元兴奋性中起着基本作用。神经元特异性kcc2（slc12a5）和神经胶质表达的kcc3（slc12a6）对于正常 …
Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and ...
Here, we will review the recent literature more specifically on (1) the subcellular distribution of KCC2 in relation with excitatory and inhibitory synapses, (2) its basic properties as well as its …
Development of KCC2 therapeutics to treat neurological disorders
Three broad classes of KCC2 therapeutics have emerged to date: (1) Small molecule direct KCC2 activators/potentiators (e.g., AXN-027; CLPs; OV350; VU0500469); (2) Small molecule indirect …
Molecular architecture of potassium chloride co-transporter KCC2
2017年11月28日 · KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain...
The potassium chloride cotransporter KCC-2 coordinates
2009年8月12日 · KCC-2 appears to establish chloride gradients required for the inhibitory effects of GABA-gated and serotonin-gated chloride channels on C. elegans behavior. In the absence …
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