2024年12月25日 · KCNE1 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1) is a Protein Coding gene. Diseases associated with KCNE1 include Long Qt Syndrome 5 and Jervell And Lange-Nielsen Syndrome 2. Among its related pathways are Cardiac conduction and Genes targeted by miRNAs in adipocytes.

KCNE1 is one of five members of the KCNE family of Kv channel ancillary or β subunits. It is also known as minK (minimal potassium channel subunit). KCNE1 is primarily known for modulating the cardiac and epithelial Kv channel alfa subunit, KCNQ1.

The KCNE1 gene provides instructions for making a protein that regulates the activity of potassium channels. These channels, which transport positively charged potassium atoms (ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.

KCNE1 single nucleotide polymorphism contributed to tinnitus that developed independently of hearing loss. KCNE1 gene abnormality and mutation is associated with long QT synrome development; KCNE1 redirects the targeting-deficient KV7.1-Y51A mutant to the apical membrane of MDCK celsl.

该基因的产物属于钾通道 KCNE 家族。 钾离子通道对许多细胞功能至关重要，并表现出高度的多样性，其电生理学和药理学特性各不相同。 该基因编码一种跨膜蛋白，已知该蛋白与 KVLQT1 基因的产物相关，可形成延迟整流钾通道。 该基因的突变与 Jervell 和 Lange-Nielsen 以及 Romano-Ward 形式的长 QT 综合征有关。 已经鉴定出编码相同蛋白质的可变剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The product of this gene belongs to the Potassium Channel KCNE family.

2021年1月21日 · Using pharmacology, gene invalidation, and single-molecule fluorescence assays, we found that KCNE1 fulfils all criteria of a bona fide auxiliary subunit of the TMEM16A chloride channel, which belongs to the anoctamin superfamily. Strikingly, assembly with KCNE1 switches TMEM16A from a calcium-dependent to a voltage-dependent ion channel.

2016年1月15日 · Slow-activating IKs channel complexes formed by KCNQ1 and KCNE1 are essential for human ventricular myocyte repolarization, while constitutively active KCNQ1-KCNE3 channels are important in the intestine.

2021年1月1日 · kcne1是一个只有129个氨基酸的蛋白，具有一个短的疏水跨膜结构域 【1】 。 当注射进入爪蟾卵细胞中时，KCNE1会产生缓慢激活的K+离子电流 【1】 。 所以 一直以来，KCNE1被认为可以编码K+离子通道的最小蛋白。

KCNE1 is an accessory beta subunit that assembles with the pore-forming alpha subunit KCNQ1 (607542) to form the slow delayed rectifier I (Ks) potassium channel, which is essential for cardiac function (summary by Osteen et al., 2010).

2024年12月10日 · Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel.