Recent studies suggest that PIP 2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of voltage-dependent gating, lipid modulation of Kv channel activation, and PIP 2 -regulation of KCNQ channels.

Voltage‐gated KCNQ channels have a high propensity for modulation by Gq‐signalling (Jentsch, 2000). In particular, activation of M1 or M3 receptors has been shown to inhibit KCNQ channel activity directly by PIP 2 depletion and indirectly by Ca 2+ ‐induced dissociation of calmodulin from KCNQ channels, which results in reduced channel ...

2004年1月27日 · Receptor-mediated modulation of KCNQ channels regulates neuronal excitability. This study concerns the kinetics and mechanism of M 1 muscarinic receptor–mediated regulation of the cloned neuronal M channel, KCNQ2/KCNQ3 (Kv7.2/Kv7.3).

2013年10月7日 · KCNQ (Kv7) channels underlie a voltage-gated K (+) current best known for control of neuronal excitability, and its inhibition by Gq/11-coupled, muscarinic signaling. Studies have indicated expression of KCNQ channels in airway smooth muscle (ASM), a tissue that is predominantly regulated by muscarin …

2019年2月2日 · KCNQ (Kv7, “M-type”) K + channels and TRPC (transient receptor potential, “canonical”) cation channels are coupled to neuronal discharge properties and are regulated via G q/11 -protein-mediated signals.

该技术利用分子生物学、病毒生物学等手段，将外源光敏感蛋白基因导入活细胞中，在细胞膜结构上表达了光敏感通道蛋白；然后通过特定波长光的照射，控制细胞膜结构上的光敏感通道蛋白的激活与关闭；光敏感蛋白的激活和关闭可控制细胞膜上离子通道的打开与关闭，进而改变细胞膜电压的变化，如膜的去极化与超极化。 当膜电压去极化超过一定阈值时就会诱发神经元产生可传导的电信号，即神经元的激活；相反，当膜电压超极化到一定水平时，就会抑制神经元动作电位的产 …

KCNQ genes encode five Kv7 K (+) channel subunits (Kv7.1-Kv7.5). Four of these (Kv7.2-Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contr …

2023年10月19日 · Here we report cryo-electron microscopy (cryo-EM) structures of human KCNQ2-CaM in complex with three activators, namely the antiepileptic drug cannabidiol (CBD), the lipid phosphatidylinositol...

2004年7月1日 · Receptor-mediated modulation of KCNQ channels regulates neuronal excitability. This study concerns the kinetics and mechanism of M1 muscarinic receptor-mediated regulation of the cloned neuronal...

2023年12月31日 · In this review, we summarize the currently available structures of KCNQ channels, analyze their special voltage gating mechanism, and discuss their activation mechanisms by both the endogenous membrane lipid and the exogenous synthetic ligands. These structural studies of KCNQ channels will guide the …