Structural and electrophysiological basis for the modulation of KCNQ1 …
2022年6月29日 · Here, we report cryogenic electron microscopic (cryo-EM) structures of Xenopus KCNQ1 bound to Ca 2+ /Calmodulin, with and without the KCNQ1 channel activator, ML277. …
Structure and physiological function of the human KCNQ1 …
2020年2月25日 · KCNQ1 is a K V channel that plays multiple physiological roles. When paired with the KCNE1 accessory protein, KCNQ1 provides the delayed-rectifier I Ks current of the …
A structure determination of the xKCNQ1-R2/CaM ion channel …
Background: Mutations of the KCNQ1 cardiac ion channel are known causes of arrhythmia disorders, including LQT-interval syndrome. This unique channel deviates from the …
Structural mechanisms for the activation of human cardiac KCNQ1 …
2022年11月11日 · In this study, we determined high-resolution cryo-electron microscopy structures of full-length human KCNQ1 with two VSD-PD coupling enhancers — the …
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified ...
2021年10月12日 · R2 and KCNQ1 appear to respond in a similar manner to increasing voltage in the presence of ML277. These single-channel results are supported by the whole-cell voltage …
Structural Basis of Human KCNQ1 Modulation and Gating
2020年1月23日 · KCNQ1, also known as Kv7.1, is a voltage-dependent K + channel that regulates gastric acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional …
<span class="fontstyle0">KCNQ1 </span><span …
KCNQ1 通道是电压门控钾通道 α 亚单位, 它和 KCNE 家族蛋白组装形成功能性钾通道。 通道的结构和功能变化影响体内多种疾病的病理生理过程。 综述从 KCNQ1 基本结构及其在多种分子 …
Voltage-gated potassium channels KCNQs: Structures, …
2023年12月31日 · This study revealed the structural basis for the KCNE3 modulation on KCNQ1, uncovered the PIP 2 binding site in KCNQ1, and presented the first open-state structure of …
Structural and electrophysiological basis for the modulation of KCNQ1 …
2022年6月29日 · Here, we report cryogenic electron microscopic (cryo-EM) structures of Xenopus KCNQ1 bound to Ca 2+ /Calmodulin, with and without the KCNQ1 channel activator, ML277. …
Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights …
2017年6月1日 · KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks) channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT …