A knockout mouse, or knock-out mouse, is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.

2020年8月17日 · A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. What are knockout mice used for?

2024年12月30日 · MGI: the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data for researching human health and disease.

全身性基因敲除KO （Conventional Knockout）小鼠，也叫完全基因敲除小鼠，通过删除靶基因部分或全部参与翻译表达的功能域，KO小鼠全身上下甚至每根毛发里目的基因都无法完整正常表达，少了这个目的基因的正常表达，就能研究相应的生理和病理会出现的改变。

The Knockout Mouse Project (KOMP) is providing critical tools for understanding gene function and the genetic causes of human diseases. Coordinated by the International Mouse Phenotyping Consortium (IMPC), an international coalition will produce and phenotype a total of 5,000 knockout mice by 2016.

基因敲除 是自80年代末以来发展起来的一种新型 分子生物学技术，是通过一定的途径使机体特定的 基因失活 或缺失的技术。 通常意义上的基因敲除主要是应用DNA 同源重组 原理，用设计的 同源片段 替代靶基因片段，从而达到基因敲除的目的。 随着 基因敲除技术 的发展，除了同源重组外，新的原理和技术也逐渐被应用，比较成功的有基因的 插入突变 和iRNA，它们同样可以达到基因敲除的目的。 基因敲除是80年代后半期应用DNA同源重组原理发展起来的。 80年代初， 胚胎 …

Through a combination of gene targeting and gene trapping, a global effort is underway to make a knockout mouse for all of the 25,000 mouse genes (Grimm, 2006). The knockout mouse has been a valuable tool for geneticists to discern the role of a gene in embryonic development and in normal physiological homeostasis.

条件性基因敲除（Conditional Knockout，CKO）小鼠，又叫组织特异性敲除小鼠，是通过染色体位点特异性重组酶系统Cre-LoxP和基因编辑技术，实现在特定的组织或细胞中基因敲除，而在其它组织或细胞中该基因表达正常的小鼠模型。

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a...

2012年6月15日 · The Knockout Mouse Project (KOMP) is a trans-National Institutes of Health (NIH) initiative that aims to generate a comprehensive and public resource comprised of mice containing a null mutation in every gene in the mouse genome. (See: The NIH Knockout Mouse Project Website [nih.gov])