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2024年12月25日 · KSR1 (Kinase Suppressor Of Ras 1) is a Protein Coding gene. Diseases associated with KSR1 include Breast Adenocarcinoma and Thyroid Cancer. Among its related pathways are Signaling downstream of RAS mutants and MAPK family signaling cascades.

Kinase suppressor of ras 1 (KSR1) is a molecular scaffold of the Raf/MEK/extracellular signal-regulated kinase (ERK) cascade that enhances oncogenic Ras signaling. ... The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83: 903–913 [Google Scholar] 37. Kortum R. L., et al. 2005. The molecular ...

Here we review literature pertaining to the molecular scaffold Kinase Suppressor of Ras (KSR) and its role in promoting signals critical to tumor maintenance. We summarize the phenotypes in knockout models, describe the role of KSR in cancer, and outline the structure and function of the KSR1 and KSR2 proteins.

kinase suppressor of Ras 1. GeneRIFs: Gene References Into Functions. SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status. Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells.

2023年7月23日 · Kinase Suppressor of RAS 1 (KSR1) is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in …

In the present article, we discuss recent findings regarding KSR1, indicating that it has dual activity as an active kinase as well as a pseudokinase/scaffolding protein. Moreover, the biological functions of KSR1 in human disorders, notably in malignancies, are also reviewed.

KSR1 contains 17 exons, 154426 base pairs. The KSR1 gene was discovered in D. melanogaster and is highly conserved along the evolutionary tree through H. sapiens. Transcription can produce two different mRNA transcripts.

Kinase suppressor of ras 1 (KSR1) is a molecular scaffold of the Raf/MEK/extracellular signal-regulated kinase (ERK) cascade that enhances oncogenic Ras signaling.

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene. KSR1 is a component of a multiprotein signaling complex that enhances phosphorylation of Raf family members, ultimately activating downstream MAP kinases.