2024年12月25日 · KSR1 (Kinase Suppressor Of Ras 1) is a Protein Coding gene. Diseases associated with KSR1 include Breast Adenocarcinoma and Thyroid Cancer. Among its related pathways are Signaling downstream of RAS mutants and MAPK family signaling cascades.

Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene. [5] [6]

1、ksr1 Ras 激酶抑制因子 1（kinase suppressor of Ras，KSR1）是一种支架蛋白，在 ERK 信号通路发挥重要作用。 KSR1 与 Raf-1、MEK、ERK 均能相互作用，功能强大[8]。

Kinase suppressor of Ras-1 (KSR1) binds each of the three ERK cascade components to facilitate pathway activation. Even though KSR1 contains a C-terminal kinase domain, evidence supporting the catalytic function of KSR1 remains controversial.

KSR1是对果蝇和秀丽隐杆线虫进行研究时发现的基因,是可被神经酰胺和生长因子调控的MAPK/ 细胞外信号调节激酶(extracellular signal regulated kinase,ERK)通路支架蛋白,其功能主要是协调装配包含Raf、丝裂原激活蛋白激酶的激酶(mitogen activated protein kinase kinase,MEK)和ERK 的多蛋白复合体并调节ERK通路的活性,在细胞增殖和分化等过程中起重要作用[1]。 最近研究显示KSR1与肿瘤的发生、发展密切相关,已成为研究的热点。 本文对KSR1的生物学结构、功能及 …

Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma.

Here we review literature pertaining to the molecular scaffold Kinase Suppressor of Ras (KSR) and its role in promoting signals critical to tumor maintenance. We summarize the phenotypes in knockout models, describe the role of KSR in cancer, and outline the structure and function of the KSR1 and KSR2 proteins.

2023年7月23日 · Kinase Suppressor of RAS 1 (KSR1) is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS-mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation.

2023年7月23日 · Kinase Suppressor of RAS 1 (KSR1) is a scaffolding protein for the RAS-RAF-MEK-ERK pathway, which is one of the most frequently altered pathways in human cancers. Previous results have shown that KSR1 has a critical role in mutant RAS-mediated transformation. Here, we examined the role of KSR1 in mutant BRAF transformation.

Kinase suppressor of RAS1 (KSR1) is a scaffold protein implicated in RAS-mediated RAF activation. However, the molecular function of KSR in papillary thyroid cancer (PTC) is unknown. Thus, this study aimed to characterize the role of KSR1 in patients with PTC. qRT-PCR and immunohistochemistry (IHC) …