Here we present an overview of recent advancements in AI applications across the entire drug development workflow, encompassing the identification of disease targets, drug discovery, preclinical and clinical studies, and post-market surveillance.

2025年1月20日 · This Review explores the state-of-the-art applications of artificial intelligence in small-molecule drug development, from target identification and drug synthesis up to clinical trial design...

Here we present an overview of recent advancements in AI applications across the entire drug development workflow, encompassing the identification of disease targets, drug discovery,...

Lifeng Kang is a Senior Lecturer at the School of Pharmacy, Faculty of Medicine and Health, University of Sydney. His laboratory is focused on microscale technologies and 3D printing for drug delivery and tissue engineering. Dr. Kang has published 3 books, 5 book chapters, 69 peer-reviewed journal articles (56 as the main author), 81 abstracts

‪Associate Professor, School of Pharmacy, Faculty of Medicine and Health, University of Sydney‬ - ‪‪Cited by 4,423‬‬ - ‪drug delivery‬ - ‪regenerative medicine‬ - ‪3D printing.‬ -...

2025年1月1日 · Deep Multiple Instance Learning is introduced in drug repositioning for the first time. Meta-path instances is elaborately designed and efficiently represented in proposed model MilGNet. MilGNet showed noteable improvements in 5 benchmarks compared with 8 baselines (10.9% on AUPR).

Current antiviral drug discovery efforts face many challenges, including development of new drugs during an outbreak and coping with drug resistance due to rapidly accumulating viral...

Small-molecule drugs are organic compounds affecting molecular pathways by targeting important proteins. These compounds have a low molecular weight, making them penetrate cells easily.

2025年1月13日 · Kang et al. 42 (2022) utilized ProtBert, a BERT-based pre-trained model for amino acids, and RoBERTa pre-trained for encoding drug SMILES format, significantly enhancing performance in affinity...