利用识别NNN PAM的SpCas9内切酶变体SpRYn，将SpCas9n替换为SpRY构建了水稻的pAKBE rBE120（TadA9-SpRYn-MPGv3）。不同内源性靶点的检验结果显示，基于SpRYn的AKBE可通过识别水稻中具有高度灵活性的PAM有效实现A-to-K的编辑。

Here, we isolated a rice endogenous hypoxanthine excision protein, N-methylpurine DNA glycosylase (OsMPG), and engineered two plant A-to-K (K = G or T) base editors, rAKBE01 and rAKBE02, for simultaneous adenine transition and transversion base editing in rice by fusing OsMPG or its mutant mOsMPG to a plant adenine transition base editor, ABE8e.

2022年5月16日 · 近年来开发的腺嘌呤和胞嘧啶碱基编辑器 (ABE和CBE)在植物上实现了精准的A-to-G和C-to-T的定点替换，稳定高效的特性使其得到了广泛的应用，但目前碱基替换类型有限。 近日，上海交通大学/中科院分子植物卓越中心陆钰明课题组与朱健康院士团队合作在《Plant Biotechnology Journal》发表了题名为“Efficient C-to-G editing in rice...

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He is a good professor and is accessible outside of class. He posts notes at the end of the week, and there are no surprises on the quiz or test; they are similar to the ones from notes or homework. This class is very fast-paced but Akbas is incredibly willing to help.

2024年4月11日 · Development of ABE and AKBE base editors in watermelon Supplementary Data.docx. Browse. Browse and Search Search. Development of ABE and AKBE base editors in watermelon Supplementary Data.docx. Download (530.65 kB) This item is shared privately. modified on 2024-04-11, 08:11. Categories No categories selected.

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