Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest in kava, the molecular target(s) of the pharmacologically active constituents, kavalactones ...

Kavalactones are a class of lactone compounds found in kava roots and Alpinia zerumbet (shell ginger). [1] and in several Gymnopilus, Phellinus and Inonotus fungi. [2] Some kavalactones are bioactive. They are responsible for the psychoactive, analgesic, euphoric and sedative effects of …

Kava (Piper methysticum) has been widely consumed for many years in the South Pacific Islands and displays psychoactive properties, especially soothing and calming effects. This plant has been used in Western countries as a natural anxiolytic in recent decades.

Kava | C14H16O3 | CID 5281052 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

The kavalactones are the main compounds of the kava drinks (see Table 1 for names and structures of the main kavalactones). There are many clinical trials on the use of kava product for anti-anxiety, and a systematic review supports the use of kava for the treatment of generalized anxiety (Sarris et al., 2009).

2019年7月22日 · Kava (Piper methysticum), an ethnomedicinal shrub native to the Polynesian islands, produces psychoactive kavalactones and anticancer flavokavains. Structures of key enzymes in their biosynthetic...

2024年10月15日 · Kavalactones are the active kava ingredients responsible for the psychoactive effects of Kava (Piper methysticum). Researchers have found around eighteen kavalactones. However, only six are usually measured because they comprise over 90% of the active compounds in kava.

2024年11月14日 · Kava (Piper methysticum), a plant native to the South Pacific islands, has garnered significant scientific interest due to its unique chemical constituents known as kavalactones and their effects on the central nervous system. This article delves into the chemical composition of kava and its mechanisms of action, bridging the gap between ...

Weng's lab has shown that if researchers figure out the genes behind a desirable natural molecule—in this case, kavalactones—they can clone those genes, insert them into species like yeast or...

2019年7月24日 · Weng's lab has shown that if researchers figure out the genes behind a desirable natural molecule—in this case, kavalactones—they can clone those genes, insert them into species like yeast or...