2024年12月25日 · KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include Epilepsy and Eye Degenerative Disease. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses.

Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K v 1.3, is a protein that in humans is encoded by the KCNA3 gene. [5] [6] [7] Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating ...

该基因编码钾通道、电压门控、摇床相关亚家族的成员。 该成员包含六个跨膜结构域，在第四部分中具有振动型重复序列。 它属于延迟整流器类，其成员允许神经细胞在动作电位后有效地复极化。 它在 T 细胞增殖和激活中起重要作用。 该基因似乎是无内含子的，它与 1 号染色体上的 KCNA2 和 KCNA10 基因聚集在一起。 [RefSeq 提供，2008 年 7 月] Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints.

Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily.

2025年2月8日 · Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in axon and plasma membrane. Is expressed in brain and heart. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Feb 2025]

We describe a novel association of de novo missense variants in KCNA3 with a human DEE, and provide evidence that fluoxetine might represent a potential targeted treatment for individuals carrying variants with significant GoF effects.

KCNA3 is expressed in microglia and likewise in T cells, it is important for their proliferation (Kotecha & Schlichter, 1999). In an attempt to mechanistically define the role of KCNA3 in pro-inflammatory microglia, the effects of blocking the channel were studied in vivo and in vitro (Rangaraju et al., 2017). Using the lipopolysaccharide (LPS ...

KCNA3，即钾电压门控通道亚家族A成员3，别名HLK3、HPCN3、Kv1.3、MK3等。 这是一种在人体中由KCNA3基因编码的电压门控钾离子通道，主要在T细胞、神经细胞和肌肉细胞中发挥作用。 KCNA3的作用机制是通过响应细胞膜电位变化，形成钾离子选择性通道，允许钾离子根据其电化学梯度通过，进而调节细胞的兴奋性，参与动作电位的复极化过程。 KCNA3基因位于1号染色体的1p13.3区域，其编码的蛋白质含有6个跨膜区，并具有一个shaker型重复序列 。 KCNA3在生 …

钾通道是功能和结构上最复杂的电压门控离子通道。 它们的多种功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。 在果蝇中已经鉴定出四个与钾通道相关的序列基因——shaker、shaw、shab和shal，每种基因都有人类同源基因。 本基因编码钾通道、电压门控、shaker相关亚家族的成员。 该成员包含六个膜跨越域，第四段有一个shaker型重复。 它属于延迟整流器类，其成员允许神经细胞在动作电位后有效地复极化。 它 …

2023年8月28日 · The potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is involved in the repolarization of nerve cells following an action potential. It also plays an essential role in T-cell proliferation and activation.