2024年12月25日 · KCNK18 (Potassium Two Pore Domain Channel Subfamily K Member 18) is a Protein Coding gene. Diseases associated with KCNK18 include Migraine With Aura 13 and Familial Hemiplegic Migraine. Among its related pathways are Cardiac conduction and Transmission across Chemical Synapses.

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K 2P 18.1 is a protein that in humans is encoded by the KCNK18 gene. K 2P 18.1 is a potassium channel containing two pore-forming P domains.

tresk k2p 钾通道 (kcnk18) 的功能缺失突变最近与典型的先兆家族性偏头痛有关。我们现在报告在无关患者中发现的额外 tresk 通道错义变异的功能特征。几个变体要么没有明显的功能效果，要么导致通道活动减少。

2025年2月8日 · Altered functional properties of a missense variant in the TRESK K(+) channel (KCNK18) associated with migraine and intellectual disability. The Background K(+) Channel TRESK in Sensory Physiology and Pain.

该基因编码含有两个成孔 P 结构域的钾通道蛋白超家族成员，编码的蛋白质起外向整流钾通道的作用。 已发现该基因的突变与先兆偏头痛有关。 [RefSeq 提供，2011 年 1 月] Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow.

2013年10月10日 · The Potassium Channel, Subfamily K, member 18 (KCNK18) gene, coding the potassium channel TRESK, is the first gene in which a rare mutation resulting in a non-functional truncated protein has been identified and causally linked to MA in a multigenerational family.

Gene ID: 445371, updated on 8-Feb-2025. Predicted to enable calcium-activated potassium channel activity; outward rectifier potassium channel activity; and potassium ion leak channel activity.

Two-pore domain (K2P) potassium channels, such as KCNK18, give rise to background, or leak, potassium conductance, and they regulate diverse cellular functions by adjusting both the resting membrane potential and excitability.

View mouse Kcnk18 Chr19:59208080-59225802 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Our study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura. However, the precise role of this gene in migraine predisposition deserves further studies.