2024年12月25日 · KDM2B (Lysine Demethylase 2B) is a Protein Coding gene. Diseases associated with KDM2B include Hematologic Cancer and Large B-Cell Lymphoma. Among its related pathways are Chromatin organization and RNA Polymerase I Promoter Opening. Gene Ontology (GO) annotations related to this gene include rRNA …

As part of the ncPRC1.1 complex, KDM2B was found to be rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote mono-ubiquitylation of histone H2A on K119 with concomitant local decrease of H2A levels and an increase of H2A.Z.

2023年10月14日 · Here we removed the chromatin-association capability of KDM2B in the progenitors of developing dorsal telencephalon (Kdm2b∆CxxC) to discover that Kdm2b∆CxxC hippocampus, particularly the...

2017年6月29日 · We interrogated 48 genes in DNA and histone modification pathways and identified KDM2B, an H3K36-specific demethylase, as a novel regulator of TRAIL response. Accordingly, silencing of KDM2B...

2023年10月，武汉大学周严教授课题组在 Nature Communications （IF=16）发表了题为“KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors”的研究论文。 该研究采用 Kdm2bfl/fl， Emx1-Creand Nestin-Cre 以及集萃药康来源的B6/JGpt-Rnf2 fl/fl/Gpt 小鼠，进行了表型分析，行为学实验，RNA-seq和ChIP-seq分析等，揭示了KDM2B在海马形态发生中的关键作用，并阐明了其通过转录沉默Wnt信号通路来调控神经前 …

2025年2月9日 · we propose histone demethylase KDM2B and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies; NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Pathogenic variants in genes involved in the epigenetic machinery are an emerging cause of neurodevelopment disorders (NDDs). Lysine-demethylase 2B (KDM2B) encodes an epigenetic regulator and mouse models suggest an important role during development. We set out to determine whether KDM2B variants are associated with NDD. Methods:

Here, we show that KDM2B, also known as FBXL10 and a member of the Jumonji C family of proteins known for its histone H3K36 demethylase activity, is a di- and trimethyl H3K79 demethylase. We demonstrate that KDM2B induces transcriptional repression of HOXA7 and MEIS1 via occupancy of promoters and demethylation of H3K79.

2019年1月11日 · KDM2B(也称为FBXL10)是组蛋白赖氨酸去甲基化酶家族成员，含有JmjC结构域，特异催化H3K4me3、H3K36me1/2和H3K79me2/3去甲基化 [8-10] 。KDM2B作为PRC1的辅因子，对调节胚胎发育、形态发生、胚胎干细胞的分化等发挥关键作用。

该基因编码 F-box 蛋白家族的一个成员，其特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。 该基因编码的蛋白质属于 Fbls 类。 已发现该基因的多个可变剪接转录本变体，但尚未确定某些变体的全长性质 …