Dysregulation of KDM4A is closely related to the onset and development of malignant tumors, making KDM4A a promising target for anti-cancer therapy. Therefore, KDM4A has been becoming a hot topic in cancer research. In this review, we discuss the structure, regulation, catalytic activity, and biological functions of KDM4A, as well as

Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene. [5][6][7] This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H domain, two …

2024年12月25日 · KDM4A (Lysine Demethylase 4A) is a Protein Coding gene. Diseases associated with KDM4A include Hyperoxaluria, Primary, Type I and Lung Sarcomatoid Carcinoma. Among its related pathways are NR1H2 and NR1H3-mediated signaling and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

2024年7月13日 · We identified histone lysine-specific demethylase 4a (Kdm4a) as a negative regulator for engram formation. Kdm4a is downregulated after neural activation and controls the volume of mossy fiber...

这种核蛋白作为三甲基化特异性去甲基化酶发挥作用，将特定的三甲基化组蛋白残基转化为二甲基化形式，并作为转录抑制因子发挥作用。 [RefSeq 提供，2009 年 4 月] This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers.

2024年3月1日 · KDM4A mediates drug resistance and lung metastasis of OS by demethylating H3K9me3 at the SLC7A11 promoter and reducing its transcription, while KDM4A inhibition can induce cell ferroptosis and reverse these processes in OS. 122 In glioma, KDM4A promotes cell survival by inhibiting autophagy in U87MG and T98G cells. 123 Mechanistically, KDM4A ...

2021年5月20日 · KDM4A, as a histone H3 lysine 9 trimethylation (H3K9me3) demethylase, has been found to play a critical role in squamous cell carcinoma (SCC) growth and metastasis. Here we report that KDM4A inhibition promoted heterochromatin compaction and induced DNA replication stress, which elicited antitumor immunity in SCC.

2021年5月19日 · Chromatin immunoprecipitation assay revealed that KDM4A promoted myogenesis by removing the histone methylation mark H3K9me3 at MyoD, MyoG and Myf5 locus. Furthermore, inactivation of KDM4A in...

2020年3月30日 · Here, we report that the loss of lysine-specific demethylase 4A (KDM4A) alters the global H3K9me3 landscape in mature oocytes at sites occupied by bdH3K4me3, thereby highlighting a key role for...

赖氨酸特异性去甲基酶 4 A（KDM4A，也称为 JMJD2A、KIA0677 或 JHDM3A）是一种去甲基酶，可以去除组蛋白 H3K9me2/3、H3K36me2/3 和 H1.4K26me2/me3 上的甲基。 越来越多的证据表明，KDM4A不仅参与机体稳态（如细胞增殖、迁移和分化以及组织发育），而且与多种人类疾 …