Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. [1] . These modifications give ketolides much broader spectrum than other macrolides.

Ketolides are a new generation of macrolide antibiotics designed to overcome issues with bacterial resistance to macrolides. They are semi-synthetic antibiotics derived from …

Ketolides are a new class of antibacterial drugs (derived from macrolides) designed specifically to fight respiratory tract pathogens that are resistant to macrolides. Ketolides work by inhibiting protein synthesis and blocking the ability of bacteria to make essential proteins required for their maintenance and survival.

Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.

Ketolides are 14-membered macrolides in which the cladinose is replaced by a keto function and which possess in their macrocycle a carbamate linked to an alkyl-aryl extension, represented by telithromycin as the only registered antibiotic. You might find these chapters and articles relevant to …

Ketolides are semisynthetic derivatives of erythromycin A, having a 3-keto function instead of an L -cladinose moiety. These compounds are unable to induce MLSB resistance and are active against inducible erm-containing Gram-positive cocci such as Staphylococcus aureus and Streptococcus pneumoniae.

Ketolides are semi-synthetic macrolide antibiotics with improved activity against several erythromycin-resistant bacterial pathogens.

2012年9月16日 · Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.

Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.

2011年11月19日 · Ketolides are not only generally more potent than macrolides against susceptible microorganisms but are also active against species that are resistant to macrolides. Ketolides have a low propensity for selection of resistant mutants and have shown less frequent development of resistance in vitro.