This tutorial review highlights recent, exciting developments in the chemistry of ketyl radicals by comparing the varied contemporary – for example, using photoredox catalysts – and more classical approaches for the generation and use of ketyl radicals.

2018年10月12日 · We report a strategy for net redox-neutral generation and reaction of ketyl radicals. The in situ conversion of aldehydes to α-acetoxy iodides lowers their reduction potential by more than 1 volt, allowing for milder access to the corresponding ketyl radicals and an oxidative termination event.

2024年9月20日 · Herein, we describe the development of an alternative strategy to access ketyl radicals from aldehydes, which avoids the reduction pathway by instead proceeding via single-electron oxidation and desulfination of α-hydroxy sulfinates.

2021年3月23日 · This tutorial review highlights recent, exciting developments in the chemistry of ketyl radicals by comparing the varied contemporary – for example, using photoredox catalysts – and more classical approaches for the generation and use of ketyl radicals.

2022年6月13日 · Here we report a multicomponent, redox-neutral photocatalytic manifold that combines readily available aldehydes, feedstock 1,3-butadiene and various nucleophiles to build architecturally complex...

Structural and Spectroscopic Characterization of a Charge-Separated Uranium Benzophenone Ketyl Radical Complex. Journal of the American Chemical Society 2008, 130 (20) , 6567-6576. https://doi.org/10.1021/ja801007q

2021年5月7日 · This tutorial review highlights recent, exciting developments in the chemistry of ketyl radicals by comparing the varied contemporary - for example, using photoredox catalysts - and more classical approaches for the generation and use of ketyl radicals.

2024年7月7日 · Here, we report the generation of the ketyl radicals and coupling with alkynes that was enabled by cost-effective chromium catalysis, allowing for the formation of valuable E -exocyclic allyl alcohols with high stereo- and chemoselectivity.

2019年12月10日 · Generation of a ketyl radical from unactivated aliphatic carbonyl compounds is an important strategy in organic synthesis. Herein, catalytic generation and use of a ketyl radical for the reductive coupling of aliphatic carbonyl compounds and styrenes by organic photoredox catalysis is described.

2014年2月24日 · Ketyls produce two types of conjugate acids: R2C.–OH and R2CH–O.. The former are α-hydroxyalkyl radicals and the latter are alkoxyl radicals, but they have also been called ketyls in photochemistry. PAC, 1995, 67, 1307.