2013年9月27日 · If you would look up the properties of KHMDS from a chemical supplier, you will find it will react violently with with water. So do keep it under inert atmosphere. As for solubility, it is a non-nucleophilic base, so probable no substitution and addition like reactions will occur. I wont suspect it will be a problem there. A comment on the use ...

2016年7月28日 · And yet, the reaction conditions are KHMDS/18-crown-6 which are clearly designed to eliminate the possibility of coordination to the potassium cation and maximise the rate of addition of the "naked" alkoxide anion to the electron deficient P.

2020年12月27日 · $\begingroup$ i understand step (a) follows The Mitsunobu reaction, and steps (d) and (e) gives the aldehyde moiety in the final product, im stuck on how the C=C is formed in steps (b) and (c), the article says sulfer is oxidized to sulfone.Then, KHMDS deprotonate the carbon next to the sulfur and reacted with acetaldehyde $\endgroup$

2024年1月28日 · The book is correct. This is a classic example of a 1,4-addition (also called a conjugate addition) of an alkyl nucleophile to an α,β-unsaturated ketone.

2016年2月18日 · Dry ice (solid carbon dioxide) sublimes at −78 °C. Dry ice and acetone are a common cold bath for chemical reactions.

2019年1月18日 · Ammonium chloride ($\ce{NH4Cl}$) is the work-up reagent that quenches the magnesium alkoxide product of the Grignard addition.

2014年12月21日 · $\begingroup$ Jori that's an excellent question. The enolization process that you refer to (e.g. removal of an alpha proton) is very different from carbonyl addition.

2017年12月31日 · According to the current version of Nomenclature of Organic Chemistry – IUPAC Recommendations and Preferred Names 2013 (Blue Book), as already mentioned in the question, the name ‘disilazane’ is no longer recommended for $\ce{H3Si-NH-SiH3}$.