2019年2月12日 · We have studied secreted factors present in the bone marrow microenvironment and identified KIAA1199 (also known as CEMIP, cell migration inducing hyaluronan binding protein) in human bone...

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. [5] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. [6] Such function has also been validated in mice. [7]

2023年4月10日 · Here, we identify KIAA1199 as a bone marrow stromal cell-secreted factor in vitro and in vivo. KIAA1199 plasma levels of patients positively correlate with osteoporotic fracture risk and...

2023年1月17日 · 2022年，我院张涛教授和任精华教授课题组在高水平期刊Hepatology(2022年IF：17.298)发表了题为“KIAA1199 drives immune suppression to promote colorectal cancer liver metastasis by modulating neutrophil infiltration”的原创研究论文，报道了肿瘤源性KIAA1199在结直肠癌肝转移灶免疫抑制微环境 ...

2021年6月1日 · KIAA1199 knockdown in liver cancer cell line (Huh7) significantly inhibited cell growth, proliferation and invasion. Mechanismly, KIAA1199 induced EMT process and enhanced the metastasis of HCC cell by regulating EGFR, STAT3 and ERK1/2 phosphorylation [48].

Genetic blockade or pharmacologic inhibition of KIAA1199 restored tumor immune infiltration, impeded tumor progression, and potentiated response to immune checkpoint blockade (ICB).

2022年12月1日 · In this study, single-cell and bulk-transcriptomic datasets analysis revealed that KIAA1199, a hyaluronic acid (HA) binding protein, was involved in glycolysis, hypoxia and angiogenesis pathways. Moreover, boosted KIAA1199 expression in PCa tissues was positively correlated with tumor stage, hypoxia-inducible factor (HIF)-1α overexpression, as ...

KIAA1199 缺陷型 hMSC（KIAA1199下调）在细胞大小、细胞长度、细胞宽长比和细胞圆度方面表现出显着变化，同时聚合肌动蛋白 (F-actin) 减少，以及 phos-CFL1 (cofflin1)、phos-CFL1 (cofflin1) 变化。

2022年8月23日 · CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix.

Mechanistically, KIAA1199 prevents oxaliplatin mediated apoptosis via up-regulated PARP1 derived from reduced endoplasmic reticulum stress induced by protein O-GlcNAcylation. In the meantime, KIAA1199 can also trigger epithelial mesenchymal transition by stabilizing SNAI1 protein via O-GlcNAcylation.