Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene. [5] [6] [7] The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division.

2024年12月25日 · KIF22 (Kinesin Family Member 22) is a Protein Coding gene. Diseases associated with KIF22 include Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2 and Desbuquois Dysplasia 1. Among its related pathways are Golgi-to-ER retrograde transport and Vesicle-mediated transport.

2024年12月10日 · Clinical resource with information about KIF22, Seventy-five genetic loci influencing the human red blood cell., Spondyloepimetaphyseal dysplasia with multiple dislocations, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

KIF22 promotes the proliferation and glycolysis of melanoma by activating EGFR/STAT3 signaling. KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis. Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma.

2024年7月19日 · Quantitative PCR and immunostaining revealed that Kif22 was highly expressed in proliferating-zone growth-plate chondrocytes. Kif22 knockdown resulted in defective mitotic spindle formation and reduced cell proliferation.

2018年1月30日 · EGF promoted the binding of CAR to the chromokinesin KIF22. KIF22-dependent regulation of microtubule dynamics led to delayed EGFR internalization, enhanced EGFR signaling, and coordination of CAR dynamics at cell-cell junctions.

2019年4月9日 · KIF22 is a chromokinesin that is required for the generation of polar ejection forces and chromosome congression (Santamaria et al., 2008). The forces required for microtubule-based movements are generated by microtubule-associated motor proteins that include cytoplasmic dynein and kinesin. See KNSL1 (148760).

2018年11月14日 · BACKGROUND Kid (kinesin-like DNA binding protein), a member of microtubule-dependent molecular motor proteins, also known as KIF22, is reported to be associated with carcinogenesis and cancer progression in different types of malignant tumor, but the biologic behavior and clinical outcome of KIF22 i …

关于 kif22 Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,790,751-29,805,385 (from NCBI) This gene has 33 transcripts (splice variants), 179 orthologues, 41 paralogues and is associated with 3 phenotypes.

2024年5月7日 · KIF22 could promote cell proliferation and cell cycle progression by transcriptionally regulating CDC25C and its downstream CDC25C/CDK1/cyclinB1 pathway to facilitate MM progression, which might be a potential therapeutic target in MM.