2024年12月25日 · KIF3A (Kinesin Family Member 3A) is a Protein Coding gene. Diseases associated with KIF3A include Endocrine-Cerebroosteodysplasia and Orofaciodigital Syndrome. Among its related pathways are Golgi-to-ER retrograde transport and Endochondral ossification with skeletal dysplasias.

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. [7]

2025年1月4日 · kinesin-like protein KIF3A, kinesin family protein 3A, microtubule plus end-directed kinesin motor 3A. GeneRIFs: Gene References Into Functions. The heterotrimeric kinesin-2 family member KIF3A directly binds to disabled-1 (Dab1). CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion.

2020年8月14日 · Single nucleotide polymorphisms (SNPs) in the gene encoding kinesin family member 3A, KIF3A, have been associated with atopic dermatitis (AD), a chronic inflammatory skin disorder.

通过cox回归模型进一步分析，我们发现kif3a高表达是影响胃腺癌患者总体生存期与无病生存期的独立危险因素。kif3a高表达的患者，肿瘤组织的转移、侵袭能力较强及预后不良。kif3a可能成为评价胃腺癌侵袭转移及预后的一种新的有效标志物。

2024年9月12日 · Title: Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Silencing of KIF3A suppressed TNBC cell proliferation by repressing the Rb-E2F signaling pathway and inhibited migration and invasion by repressing epithelial-mesenchymal transition.

KIF3A（激动素家族成员3A）是一种蛋白质编码基因。 与KIF3A相关的疾病包括Usher综合征，I型和神经元性类脂褐素病。 其相关途径包括囊泡介导的运输和高尔基体到ER的逆行运输。 与该基因相关的基因本体论（GO）注释包括ATPase活性和微管结合。

We have investigated the distribution of KIF3A, a member of the heteromeric family of kinesins, in the vertebrate retina. We find KIF3A at two distinct sites within photoreceptors: at the basal body of the connecting cilium axoneme and at the synaptic ribbon.

2025年2月8日 · Airway epithelial KIF3A suppresses Th2 pulmonary inflammation and airway hyperresponsiveness following aeroallergen exposure, implicating epithelial microtubular functions in the pathogenesis of Th2-mediated lung pathology.

Enables protein Phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole and centrosome. Part of Kinesin II complex. Colocalizes with spindle microtubule. [provided by Alliance of Genome Resources, Apr 2022]