Protein kinase A - Wikipedia
Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase, abbreviated to PKA, was discovered by chemists Edmond H. Fischer and Edwin G. Krebs in 1968.
蛋白激酶A - 百度百科
蛋白激酶A（protein kinase A，PKA）又称依赖于cAMP的蛋白激酶A（cyclic-AMP dependent protein kinase A），是一种结构最简单、生化特性最清楚的蛋白激酶。 PKA全酶分子是由四个亚基组成的四聚体，其中两个是调节亚基（regulatory subunit，简称R亚基），另两个是催化亚基 ...
蛋白激酶A - 维基百科，自由的百科全书
蛋白激酶A （英語： Protein kinase A，简称为 PKA）在 细胞生物学 中是指其活性取决于细胞 环腺苷酸 （cAMP）水平的一家族 酶 类。 蛋白激酶A也被称为 环腺苷酸依赖性蛋白激酶 （EC 2.7.11.11）。 蛋白激酶A在细胞中具有多种功能，包括对 糖原 、 糖 以及 脂类 代谢 的调控。 PKA在细胞内参与多种生物学过程的调控，包括细胞增殖、细胞分化、细胞凋亡、代谢调节等。 例如，在细胞增殖中，PKA可以磷酸化转录因子和细胞周期蛋白，调控基因表达和细胞周期的进 …
The structures of protein kinase A in complex with CFTR: …
Protein kinase A (PKA) is a key regulator of cellular functions by selectively phosphorylating numerous substrates, including ion channels, enzymes, and transcription factors. It has long served as a model system for understanding the eukaryotic kinases.
Physiological and pathological roles of protein kinase A in the heart
Protein kinase A (PKA) is a central regulator of cardiac performance and morphology. Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress signals, most notably catecholamines secreted by the sympathetic nervous system.
Protein Kinase A - Madame Curie Bioscience Database - NCBI Bookshelf
Among these general cellular mechanisms, the cAMP-dependent protein kinase (protein kinase A, PKA) signaling pathway in CA1 stands out for several reasons.
Protein Kinase A - Colorado State University
Like other protein kinases, protein kinase A (also known as the cyclic AMP-dependent protein kinase or A kinase) is an enzyme that covalently decorates proteins with phosphate groups. The unique characteristic of protein kinase A is that its activity is regulated by fluctuating levels of cyclic AMP within cells (hence its alias as the cyclic ...
The structures of protein kinase A in complex with CFTR
2024年11月4日 · Protein kinase A (PKA) is a key regulator of cellular functions by selectively phosphorylating numerous substrates, including ion channels, enzymes, and transcription factors. It has long served as a model system for understanding the eukaryotic kinases. Using cryoelectron microscopy, we present com …
A型激酶锚定蛋白及其复合物结构与功能
A型激酶锚定蛋白 (A-kinase anchoring proteins，AKAPs)是一类结构不同而功能相关的蛋白家族，其主要功能是将cAMP依赖性蛋白激酶A（PKA）锚定于特定的亚细胞结构.PKA是第二信使cAMP的主要效应器，而AKAPs在靶向定位和调节PKA介导的磷酸化事件方面扮演重要角色....
The Tails of Protein Kinase A - PubMed
Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R)-subunit dimer and two catalytic (C)-subunits. There are two major families of C-subunits, C α and C β, and four functionally nonredundant R-subunits (RI α, RI β, RII α, RII β).