In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

kinase, an enzyme that adds phosphate groups (PO 43−) to other molecules. A large number of kinases exist—the human genome contains at least 500 kinase-encoding genes. Included among these enzymes’ targets for phosphate group addition (phosphorylation) are …

2023年12月1日 · Kinases are enzymes responsible for relaying signals in and out of cells, allowing them to respond adaptively to their environment. Kinases influence almost all cellular activities, ranging from proliferation and remodeling to differentiation and programmed cell death.

2025年3月13日 · They function in cascades, where one kinase activates another, amplifying the signal. Structural studies have shown that MAPKs contain a conserved activation loop that requires phosphorylation for full activity. Dysregulation of serine/threonine kinases has been implicated in diseases such as cancer and diabetes, making them important ...

2022年3月3日 · Regulation and Function of Protein Kinase. There are about 500 protein kinase encoding genes in the human genome which represents 2% of all the human genes. Kinase is the name given to an enzyme that adds a phosphate group (PO 4 3-) to other biomolecules such as protein, lipid, or nucleotides. This type of addition of a phosphate group is ...

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

6 天之前 · Protein kinases are a class of enzymes that play a crucial role in cellular signaling and regulation. They are responsible for catalyzing the transfer of phosphate groups from high-energy molecules, such as ATP, to specific amino acid residues on target proteins.

Protein kinases are a class of enzymes that play a key role in regulating cell function. They achieve this by catalyzing the transfer of a phosphate group from ATP to one or more amino acids in the side chain of a protein, resulting in a conformational change that affects protein function.

2025年3月13日 · Kinases regulate cellular processes by transferring phosphate groups from high-energy molecules like ATP to specific substrates. This phosphorylation event can dictate whether a protein is active or inactive, influence its stability, or determine its …

4 天之前 · Protein Kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families. By adding phosphate groups to substrate proteins, they direct the activity, localization and overall function of many proteins, and serve to orchestrate the activity of almost all cellular processes.