Immortalized Human Mast Cell Line (LUVA) that is easily cultured without growth factors. Highlights: Fast growing and increased life span, compared to typical blood-derived CD34+ cells; Proliferate independent of exogenous stem cell factors; Contain granules and express high levels of mast cell cytokines, prostaglandins and leukotrienes

LUVA cells are an immortalized human MC line that can be maintained without stem cell factor and display high levels of normally signaling c-kit and FcεRI. These cells will prove valuable for functional human MC studies.

LUVA cells are an immortalized human mast cell line that can be maintained without stem cell factor and display high levels of normally signaling c-kit and FcεRI. These cells will prove valuable for functional human mast cell studies. Keywords: Mast cell, SCF, FcεRI, c-Kit, Tryptase, CPA3.

The LUVA cell line allows for a proper in vitro mast cell model in which researchers can study the mechanisms which cause mastocytosis, a condition where mast cells aggregate in certain parts of the body. 2

The LUVA cell line is a human mast cell in vitro cell model used to study the mechanisms which cause mastocytosis, inflamation and allergic responses. Key Applications: Cell Culture; Application Notes

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... our knowledge, LUVA cells are the first human MC line derived from a subject without a clonal MC disorder (based on a normal serum tryptase level and the lack of a mutation in KIT). LUVA...

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