Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. [1][2] In humans, they are encoded in the leukocyte receptor complex (LRC) on chromosome 19q13.4; the KIR region is approximately 150 kilobases and contains ...

2022年3月8日 · Deamidated gliadin derived from dietary gluten is the antigen for CD4 + T cells that drives autoimmune enteropathy in human CeD (11, 12). Therefore, we explored whether KIR + CD8 + T cells can suppress gliadin-specific CD4 + T cells from CeD patients.

2003年5月28日 · KIR genes are tandemly arrayed over about 150 kb, with the remarkable feature that gene content varies between haplotypes. The discovery of KIR has also imparted an additional function on the human leukocyte antigen (HLA) class I molecules, which are encoded by genes within the major histocompatibility complex (MHC; chromosome 6).

Killer cell immunoglobin-like receptor (KIR) interactions with their cognate ligands, human leukocyte antigen (HLA) class I molecules, adapt to these challenges through intricate co-evolution. Unlike the molecular mediators of adaptive immunity, KIR and HLA polymorphism is genetically driven, and therefore subject to natural selection, but with ...

2022年7月1日 · Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive immunity. The extreme diversity of this interaction is genetically determined, having evolved in the ever-changing environment of pathogen exposure.

KIR genes are encoded within a 150 Kb stretch of the 1 Mb long extended LRC on chromosome 19. The extended LRC also contains the genes encoding DAP adaptor proteins, CD66 antigens as well as SIGLEC, FcGRT, LILR, LAIR, FcAlphaR and NCR1 receptors.

2024年11月28日 · Here we identify a subpopulation of CD8+ T cells that are tumor-antigen-specific and can be identified by KIR expression but paradoxically impair anti-tumor immunity in patients with melanoma.

2017年6月1日 · The killer cell immunoglobulin-like receptor (KIR) region of human chromosome 19 contains up to 16 genes for natural killer (NK) cell receptors that...

2023年3月28日 · Subsets of the human CD8 + T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In the present study, we examine the phenotypic and functional characteristics of …

2022年3月3日 · Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive immunity. The extreme diversity of this interaction is genetically determined, having evolved in the ever-changing environment of pathogen exposure.