2021年6月18日 · Inward rectifying potassium (Kir) channels play important roles in both excitable and nonexcitable cells of various organ systems and could represent valuable new drug targets for cardiovascular, metabolic, immune, and neurological diseases.

2020年12月1日 · 杀伤细胞免疫球蛋白样受体，常缩写为“ KIR ”（英语： Killer-cell immunoglobulin-like receptors），是 免疫系统 重要成员的 自然杀伤细胞 （NK cell) 表面的一组蛋白。 这些受体蛋白可以通过与 第一型 主要组织相容性复合体 （MHC class I）相互作用而调节细胞的杀伤功能。 [1] KIR蛋白由19号染色体长臂（19q13.4）的一组同名基因编码。 这些基因的 多态性 很高，既表现在单个基因是否出现，也表现在基因的等位基因的不同。 [2] 根据受体蛋白 …

2019年12月1日 · A livello uterino, tutte le donne hanno alcune cellule con un recettore chiamato KIR che presenta tre grandi gruppi genetici: KIR AA, KIR AB e KIR BB. Questi recettori sono responsabili di...

杀伤细胞免疫球蛋白样受体 (KIR)是在自然杀伤NK细胞表面呈克隆性分布、能够识别靶细胞上相应HLA Ⅰ类分子表位、调节NK细胞活性的一类具有抑制和激活功能的重要受体.KIR基因家族呈随机性、多样性和单一等位基因表达模式.KIR的基因型决定其表达谱,并对KIR的表达频率具有微调作用.转录因子参与调节KIR表达.KIR基因的克隆性表达主要受表观遗传调控,通过DNA甲基化作用维持.对NK细胞KIR表达机制的深入研究有助于在感染性疾病、妊娠、自身免疫性疾病及造血干细 …

2014年10月23日 · Our results show that using a KIR haplotype B donor is associated with lower relapse risk and better EFS after T-cell-depleted haploidentical HSCT in childhood ALL. In addition, we demonstrate a correlation of donor high KIR B-content score with better probability of EFS and lower relapse risk.

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KIR-HLAC genotyping is a genetic test that allows to assess the risks of the embryo being rejected by the maternal immune system, and thus to direct medical interventions in order to achieve a successful pregnancy. What is KIR-HLAC genotyping?

Killer immunoglobulin‐like receptors (KIR s) regulate the activation of natural killer cells through their interaction with human leucocyte antigens (HLA ). KIR and HLA loci are highly polymorphic, and certain HLA ‐KIR combinations have been found to protect against viral infections.

2021年7月14日 · Our results demonstrate that Drice restrains inflammatory signalling induced by commensal bacteria in the fly intestine by forming a complex with Diap2. This triggers proteasomal degradation of the...

2021年3月30日 · DIAP Communication Protocol Service Manual Bookreader Item Preview ... -l ltz+kir+bul+ind+eng+swa+lat+mon+que+Latin+Cyrillic Ppi 300 Scanner Internet Archive Python library 1.9.6 . Show More. plus-circle Add Review. comment. Reviews There …