Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven subfamilies have been identified in various mammalian cell types, [1] plants, [2] and bacteria. [3] They are activated by phosphatidylinositol 4,5-bisphosphate (PIP 2).

Inwardly rectifying K (+) (Kir) channels allow K (+) to move more easily into rather than out of the cell. They have diverse physiological functions depending on their type and their location. There are seven Kir channel subfamilies that can be classified …

Einwärts gleichrichtende Kaliumkanäle, kurz Kir-Kanäle, sind Kaliumkanäle, die aus zwei Transmembrandomänen und einer P-Schleife bestehen. Ihre Leitfähigkeit nimmt bei …

In the present review we focus on placing the physiology and pharmacology of this K + channel family in the context of atomic resolution structures and in providing a glimpse of the promising future of therapeutic opportunities.

2022年2月8日 · A family of inwardly rectifying potassium (Kir) channels helps cells maintain K + levels. Encoded by KCNJ genes, Kir channels are comprised of a tetramer of Kir subunits, each of which contains two-transmembrane domains. The assembled Kir channel generates an ion selectivity filter for K + at the monomer interface, which allows for K + transit.

2020年5月21日 · Inward rectifier potassium (Kir) channels play diverse and important roles in shaping action potentials in biological membranes. An increasing number of diseases...

2021年8月4日 · In the present review we focus on placing the physiology and pharmacology of this K + channel family in the context of atomic resolution structures and in providing a glimpse of the promising future of therapeutic opportunities.

There are seven Kir channel subfamilies that can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated Kir channels (Kir3.x) are regulated by G protein-coupled receptors, ATP-sensitive K channels (Kir6.x) are tightly linked to cellular metabolism, and K transport channels (Kir1.x ...

2022年1月1日 · Kir channels modulate cell excitability, being involved in repolarization of action potentials (Fig. 1), setting the resting potential (Fig. 1) of the cell, and contributing to potassium homeostasis. The role of inward rectifier (Kir) channels in cardiac action potentials.

2021年6月18日 · Inward rectifying potassium (Kir) channels play important roles in both excitable and nonexcitable cells of various organ systems and could represent valuable new drug targets for cardiovascular, metabolic, immune, and neurological diseases.