The IPD-KIR Database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic …

KIR-ligands can be grouped into three major categories based on the KIR-binding epitope in HLA-C and HLA-B. Most HLA-C alleles are of the C1 or C2 group (2) and most HLA-B alleles can …

2019年5月27日 · In turn, NK cell clones were fundamental for the discovery of both killer immunoglobulin-like receptors (KIRs) and natural cytotoxicity receptors (NCRs), the two most …

KIR inhibitory receptors signal through their immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic domain. When inhibitory KIR receptors bind to a ligand, their ITIMs are …

2021年2月2日 · 杀伤细胞免疫球蛋白样受体（KIRs）在记忆性T细胞和NK细胞上表达，是NK细胞功能的关键调节因子。 KIR及其配体MHC-I类（HLA-A、-B、-C）分子具有高度多态性，特殊 …

Natural killer (NK) cells are considered crucial for the elimination of emerging tumor cells. Effector NK-cell functions are controlled by interactions of inhibitory and activating killer-cell …

To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR). The major histocompatibility complex (MHC) class I …

KIR proteins possess characteristic Ig-like domains on their extracellular regions, which in some KIR proteins are involved in HLA class I ligand binding. They also possess transmembrane …

2022年7月1日 · Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens (HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

2006年8月24日 · We developed a polymerase chain reaction-sequence specific primer (SSP)-based assay to genotype 194 UC patients and 216 control individuals for 14 KIR genes, the …