The killer immunoglobulin-like receptor (KIR) locus comprises a family of related genes that encode a group of these activating and inhibitory receptors expressed on NK cells. Recognition of self-human leukocyte antigen (HLA) class I ligands by inhibitory KIR allows NK cells to identify and inhibit the response to normal cells (3, 4, 5).

Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. [1][2] In humans, they are encoded in the leukocyte receptor complex (LRC) on chromosome 19q13.4; the KIR region is approximately 150 kilobases and contains ...

2003年5月28日 · The KIR locus, containing a family of polymorphic and highly homologous genes, maps to chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The LRC also encodes the leukocyte Ig-like receptor family (LILR), the leukocyte-associated inhibitory receptor (LAIR) family, and the Fcα receptor.

2017年6月1日 · We present a unique approach to haplotype the KIR loci using single-molecule, real-time (SMRT) sequencing. Using this method, we have—for the first time—comprehensively sequenced and phased...

2014年12月11日 · In this study, using genotyping and sequencing data of intergenic regions, we have investigated the KIR gene locus in more detail and mapped the KIR loci of >400 Caucasian individuals. This...

Prominent among these are the killer cell immunoglobulin-like receptors (KIR), a family of genes clustered in one of the most variable regions of the human genome. Within this review we discuss the vast polymorphism of the KIR gene complex which rivals that of the human leucocyte antigen (HLA) complex. There are several aspects to this ...

The killer cell immunoglobulin-like receptors (KIR) are one of the main types of MHC class I-specific receptors utilized by human NK cells, and they are comprised of both activating and inhibitory counterparts that are encoded by highly homologous sequences. The KIR locus maps to chromosome 19q13.4 within the leukocyte receptor complex (LRC) (10).

2002年4月10日 · Natural killer (NK) and some T cells express killer cell immunoglobulin-like receptors (KIRs), which interact with HLA class I expressed by target cells and consequently regulate cytolytic...

The genes encoding the killer immunoglobulin-like receptors (KIR) are situated within a segment of DNA that has undergone expansion and contraction over time due in large part to unequal crossing over.

2019年5月27日 · In turn, NK cell clones were fundamental for the discovery of both killer immunoglobulin-like receptors (KIRs) and natural cytotoxicity receptors (NCRs), the two most important steps toward unraveling NK cell function.