2024年12月25日 · KIR2DL3 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 3) is a Protein Coding gene. Diseases associated with KIR2DL3 include Graft-Versus-Host Disease and Prostate Cancer. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

KIR2DL3, Killer cell immunoglobulin-like receptor 2DL3 is a transmembrane glycoprotein expressed by the natural killer cells and the subsets of the T cells. The KIR genes are polymorphic, which means that they have many different alleles.

2021年4月12日 · KIR2DL2 and KIR2DL3 are two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family that share a common HLA-I preference in binding HLA from the C1 group.

Single Nucleotide Polymorphism in KIR2DL3 gene is associated with Asthma and Atopic Dermatitis. KIR2DL3 has previously been identified as important for clearance of the Hepatitis C virus after established infection,not found to be relevant to resistance to Hepatitis C infection.

2021年8月4日 · KIR2DL1, KIR2DL2 and KIR2DL3 are the most described receptors that recognize HLA-C molecules depending on the nature of amino acid at position 80 and leads to 2 groups of ligands : C1 (Asn80) and...

2024年2月28日 · 研究人员发现一种名为Lacutamab的人源化单克隆抗体，靶向KIR3DL2，能够通过抗体依赖的细胞毒性（ADCC）诱导KIR3DL2阳性的皮肤T细胞淋巴瘤（CTCL）细胞凋亡。 一项I期临床试验表明Lacutamab在安全性和有效性上表现良好，目前正在进行I期评估（clinicaltrials gov. Identifier：NCT03902184）。 作者认为，靶向KIR3DL2的治疗可能是一种有前景的新策略，用于治疗对常规化疗无效或耐药的KIR3DL2阳性的T细胞淋巴瘤患者。 今天，我们一起来了 …

2015年5月7日 · Allelic polymorphism significantly affected the phenotypic expression of all KIR analysed, whereas HLA ligand background influenced the expression levels of 2DL1 and 2DL3. In particular, we found...

2021年4月12日 · The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3 and HLA-C1 are highly polymorphic, with this vari …

2024年4月24日 · 杀伤细胞免疫球蛋白样受体(Killercellimmunoglobulin-likereceptor，KIR)广泛分布于自然杀伤细胞(naturalKiller，NK)表面，部分分布于细胞毒性T淋巴细胞上，KIR—L系列包括KIR2DL1、KIR2DL3和KIR2DL4，在几种疾病中具有重要的功能。

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.