KIR receptors can distinguish between MHC I allelic variants, which allows them to detect virally infected cells or transformed cells. KIRs are paired receptors, meaning some have activating and others have inhibitory functions; most KIRs are inhibitory: their recognition of MHC molecules suppresses the cytotoxic activity of their NK cell.

2023年2月24日 · 激活性受体包括激活性杀伤细胞Ig样受体（KIR）、活化性受体（NKG2D）以及自然细胞毒性受体（NCR），激活性KIR可识别经典型的MHC-I类分子，而NKG2D则识别非经典型MHC-I类分子。 抑制性受体包括抑制性KIR和异源二聚体NKG2A/CD94受体，抑制性KIR可识别经典MHC-I类分子，而NKG2A/CD94则识别非经典MHC-I分子。 MHC-I抗原特异性的抑制性受体，可密切调节NK细胞介导的细胞毒性和淋巴因子的产生。 一些KIR家族成员（KIR2DL1/2/3/5 …

2024年12月1日 · Natural killer (NK) cells play important roles in many human diseases and are regulated by interactions between killer-cell immunoglobulin-like receptors (KIRs) and their ligands, human leukocyte antigen (HLA)-class I (HLA-I) molecules.

To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR). The major histocompatibility complex (MHC) class I molecules are important ligands for KIR receptors.

2019年5月27日 · The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (KIRs), and of activating receptors has been fundamental to unravel NK cell function and the molecular mechanisms of tumor cell killing.

2023年3月28日 · KIRs and NKG2A deliver inhibitory signals to NK cells by recognizing MHC molecules that tend to be downregulated in virus-infected or tumor cells, allowing NK cells to kill their target cells. 6,7,8 KIRs include KIR2DL1, KIR2DL2/3, and KIR3DL1, which bind to HLA-C C2, HLA-C C1, and HLA-Bw4, respectively. 9 NKG2A is a member of the CD94/NKG2 ...

2024年11月21日 · Recent data have exposed differences between killer-cell immunoglobulin-like receptors (KIRs) in their selective binding to human leukocyte antigen (HLA) class I (HLA-I)-bound peptides. These differences range from being peptide …

2023年6月16日 · Killer cell immunoglobulin-like receptors (KIRs) can inhibit or activate NK cells by recognizing and binding human leukocyte antigen (HLA) class I ligands 6, 7.

2022年8月20日 · Adaptive natural killer (NK) cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs) can be expanded in vivo in response to human cytomegalovirus (HCMV) infection. Developing a method to preferentially expand this subset is essential for effective targeting of allo …

2017年5月25日 · In particular, donor-derived KIR2DS1+ NK cells were shown to efficiently kill HLA-C2+ leukemia blasts, which indicate that activating KIRs can have a role in mediating anti-leukemic or...