KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. For research use only. We do not sell to patients. * Please select Quantity before adding items. This product is a controlled …

2024年3月7日 · To study the direct transcriptional mechanisms of MYC at enhancers, we used the small-molecule inhibitor KJ-PYR-9 to acutely perturb MYC function.

2018年7月3日 · KJ-Pyr-9, was reported to bind MYC, but not MAX, with a K d of 6.5 nM in a Backscattering Interferometry (BSI) assay 27.

2014年8月11日 · KJ-Pyr-9 preferentially interferes with the proliferation of MYC-overexpressing human and avian cells and specifically reduces the MYC-driven transcriptional signature. In vivo, KJ-Pyr-9 effectively blocks the growth of a xenotransplant of MYC-amplified human cancer cells.

KJ Pyr 9 is a high affinity Myc inhibitor (K d = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant. The technical data provided above is for guidance only.

KJ Pyr 9 | C22H15N3O4 | CID 85855478 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2024年7月1日 · Interestingly, through high-throughput drug screening, three small molecules targeting the TNF/IL-17/MAPK signaling pathway were identified, including OUL35, KJ-Pyr-9, and CID44216842, which not only alleviated the hE2A-PBX1-induced myeloid hyperplasia in zebrafish but also inhibited the growth and oncogenicity of human pre-B ALL cells with E2A ...

KJ Pyr 9 is a high affinity Myc inhibitor (K d = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant. The technical data provided above is for guidance only.

KJ Pyr 9 is a novel small molecule inhibitor of MYC, with the Kd value of 6.5 ± 1.0 nM. Besides, KJ Pyr 9 also suppresses the formation of MYC-MAX and oncogenic transformation induced by MYC in cell culture [1].

A cell-permeable, blood-brain barrier permeant, bioavailable trisubstituted pyridine compound that inhibits c-Myc transcriptional activity. Shown to directly bind to both the monomeric c-Myc (K d = 6.5 nM) and to c-Myc-Max heterodimer (K d = 13.4 nM) with high affinity and disrupt c …

KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. KJ Pyr 9 (KJ-Pyr-9) 在蛋白质片段互补试验中干扰细胞中 MYC-MAX 复合物的形成 [1]。 KJ Pyr 9 在细胞培养中特异性抑制 …

2021年1月4日 · KJ-Pyr-9 was isolated from a Kröhnke pyridine library where fluorescence polarisation (FP) was used to screen for c-Myc/Max dimerization inhibitors [130]. KJ-Pyr-9 has also demonstrated anti-cancer activity in vivo, inhibiting tumor growth in a human triple-negative breast cancer xenograft model with no acute toxicity.

2015年8月1日 · We have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. KJ-Pyr-9 functions as an inhibitor of MYC in biochemical assays, in cells and in xenograft experiments. In vitro, KJ-Pyr-9 binds to MYC as well as MYC-MAX dimers and can disrupt binding of MYC-MAX dimers with E-box DNA.

结果研究者发现了一种名为KJ-Pyr-9的分子，随后研究人员利用细胞系和啮齿类动物模型进行了相关研究，研究发现，如果利用KJ-Pyr-9分子来处理细胞就会导致依赖MYC的细胞发生死亡。

A cell-permeable, blood-brain barrier permeant, bioavailable trisubstituted pyridine compound that inhibits c-Myc transcriptional activity. Shown to directly bind to both the monomeric c-Myc (K d = 6.5 nM) and to c-Myc-Max heterodimer (K d = 13.4 nM) with high affinity and disrupt c …

KJ Pyr9是一种新型MYC抑制剂。 体外实验中,KJ Pyr9抑制MYC的Kd值为6.5±1.0nM。 注：本品仅可用于科研实验，严禁用于临床医疗及其他用途！ CAS号：581073-80-5 纯度：98.98% 分子式：C22H15N3O4 分子量：385.37 结构式：

KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. KJ Pyr 9 (KJ-Pyr-9) interferes with MYC-MAX complex formation in the cell in a protein fragment complementation assay[1]. …

Effectively prevents focal microtumors formation following N-Myc, c-Myc, as well as ATG- or CAG-c-Myc transformation of cultured chick embryo fibroblasts/CEF (>99.9% inhibition at 10 µM in …

2018年8月3日 · Small molecules inhibiting MYC, such as Mycro3 and KJ-Pyr-9, have demonstrated anti-cancer activity in vivo in a Kras-induced pancreatic cancer model [58] and in a TNBC xenograft [25].

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