2002年1月14日 · We have found that KK mice in our laboratory (KK/San) have significantly low plasma lipid levels despite signs of hyperinsulinemia and hyperglycemia. Genetic analysis shows that the mutant...

2002年9月13日 · KK/San mice show low plasma lipid levels compared with wild-type KK mice despite showing signs of hyperglycemia and hyperinsulinemia. Recently, we identified a mutation in the gene encoding angiopoietin-like protein 3 (Angptl3) in KK/San mice, and injection of adenoviruses encoding Angptl3 or recombinant ANGPTL3 protein to mutant KK/San mice ...

2003年2月7日 · Our previous work identified a genetic mutation in the gene encoding angiopoietin-like protein 3 (Angptl3) in KK/Snk mice (previously KK/San), a mutant strain of KK obese mice. KK/Snk had significantly lower plasma …

2003年6月13日 · The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly low plasma triglyceride levels. In KK/San mice, genetic analysis identified a mutation in the gene encoding angiopoietinlike protein 3 (Angptl3), a liver-specific secretory protein, which had suppressive …

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In one strain (KK/San), we observed abnormally low plasma lipid levels (hypolipidemia). This mutant phenotype is inherited recessively as a mendelian trait. Here we report the mapping of the hypolipidemia (hypl) locus to the middle of chromosome 4 and positional cloning of the autosomal recessive mutation responsible for the hypolipidemia.

血管生成素样蛋白4在小鼠中是一种有效的高脂血症诱导因子，也是脂蛋白脂肪酶的抑制剂。 对具有独特的低甘油三酯血症表型的KK / San，肥胖和糖尿病模型小鼠的研究显示，血管生成素样蛋白3（ANGPTL3）调节小鼠的脂质代谢。 为了确定其他ANGPTL的脂质调节作用，我们集中在ANGPTL4上，该总体表现出与ANGPTL3的显着相似性。 出人意料的是，在KK / San小鼠中静脉注射ANGPTL4蛋白迅速增加了循环血浆脂质水平，其速率高于ANGPTL3蛋白。 此 …

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2024年5月7日 · Oct. 07 - San Francisco, CA - The Regency Ballroom. KK'S PRIEST's first-ever U.S. headlining tour, which featured support from L.A. GUNS and BURNING WITCHES, kicked off on March 7 in Fort ...

2002年9月13日 · KK/San is a mutant mouse strain established in our laboratory from KK obese mice. KK/San mice show low plasma lipid levels compared with wild-type KK mice despite showing signs of hyperglycemia and hyperinsulinemia.