2024年12月25日 · KLK2 (Kallikrein Related Peptidase 2) is a Protein Coding gene. Diseases associated with KLK2 include Prostate Disease and Prostate Cancer. Among its related pathways are Signaling by Rho GTPases and RNA Polymerase I Promoter Opening. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity.

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue. [3] [4] [5] [6]

KLK又称 血管舒缓素，是 激肽系统 的主要限速酶，它是一组存在于多数组织和体液中的 丝氨酸 蛋白酶，是一种 肽链 内切酶。 它特异性的在碳末端切割底物肽，可裂解 激肽原 释放具有活性的激肽，由激肽发挥对 心血管系统 及肾脏功能的调节作用。 KLK分为两大类：血浆KLK和组织KLK，分别由前 激肽 释放酶（pre?kallikrein）和KLK前体（prokallikrein）转换而来。 它们在分子量、底物、免疫学特性、 基因结构 和释放的激肽种类方面有很大差异。 血浆KLK又称Fletcher因子， …

Recombinant hK2 activates ERK1/2 signaling of prostate cancer cell lines, which express both PAR1 and PAR2. The two novel ETV4 fusion partners possess as predominant common characteristics androgen-induction and prostate-specific expression. Observational study of gene-disease association.

The KLK2 gene (initially termed human glandular kallikrein 1, hGK-1 and later human kallikrein 2, hK2) was first cloned from a human genomic library by using a mouse tissue kallikrein cDNA probe [1]. The enzyme has also been termed hKK-3 [1–3].

2014年12月5日 · Human kallikrein-related peptidase 2 (KLK2) is a tryptic serine protease predominantly expressed in prostatic tissue and secreted into prostatic fluid, a major component of seminal fluid. Most likely it activates and complements chymotryptic KLK3 (prostate-specific antigen) in cleaving seminal clott …

2023年6月21日 · klk在癌症中具有促肿瘤（klk3、klk7）或抑肿瘤（klk10）作用。 KLK中过多的分子网络机制，包括与 uPA 、 PAR 、 激肽 、 TGF-b 和 MMP 之间的串扰，共同促进癌细胞的存活、增殖和扩散。

2022年1月31日 · Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment. KLKs are proteolytic enzymes regulating multiple functions of bioactive...

Recent data suggested that tissue human kallikrein 2 (KLK2) might be involved in the carcinogenesis and tumor metastasis of prostate cancer (PCa). However, the detailed pathophysiological roles of KLK2 in PCa remain unclear. We report here that KLK2 may be treated as a potential therapeutic target i …

Background: Kallikrein-related peptidase 2 (KLK2)-like KLK3 (prostate-specific antigen [PSA])-belongs to the highly conserved serine proteases of the glandular kallikrein protein family (KLK family). Studies suggested that measurement of KLK2 serum levels advanced the predictive accuracy of PSA testing in prostate cancer.