Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third
2020年4月17日 · To test how klotho might push back dementia, Belloy and colleagues examined longitudinal data from the ADC, ADNI, and ROSMAP cohorts. Among 1,997 cognitively normal APOE4 carriers, klotho VS heterozygotes had a hazard ratio of 0.64 for developing mild cognitive impairment or AD over a period of three years compared with klotho homozygotes.
Klotho VS Variant Preserves Memory by Preventing Tangles
2020年8月14日 · The effect of klotho on tau was mostly observed in the brain regions where klotho mRNA is highly expressed, such as the temporal lobe, suggesting a local effect of klotho on tau pathology and/or on the interaction between amyloid and tau. This study adds evidence that the association between amyloid and tau pathologies is dependent on genotype.
Association of Klotho-VS Heterozygosity With Risk of ... - ALZFORUM
2020年4月17日 · It would be interesting to quantify klotho levels in a subgroup of control, MCI, and AD individuals with KL-VS with APOE4 and APOE3. If klotho levels are similar in APOE4 and 3 carriers, perhaps the modifications caused by the two amino acid substitutions in KL-VS could explain the intriguing interplay between klotho and APOE4.
Is Klotho’s Partner FGF23 a Cognition Protein? - ALZFORUM
2019年3月20日 · From studies of Klotho, e.g. genetic studies, the KL-VS variant is associated with normal cognitive abilities and is related to synaptic glutamate functions, which is a mechanism for normal learning abilities. Klotho is associated with a broad range of maladies including cardiovascular diseases, kidney dysfunction, and cognitive disabilities.
Shot of Klotho Boosts Memory In Aging and Diseased Mice
2017年8月15日 · Klotho recently gained wide attention because of its lifespan-extending benefits in people and mice that express higher levels or variants (Kurosu et al., 2005; Arking et al., 2002). As notable—and mysterious—is an apparent brain-boosting power in mice and association with better cognitive function in humans ( May 2014 news on Dubal et al ...
Brain-Specific Klotho Isoform Fortifies Memory - ALZFORUM
2017年11月10日 · Expressing a specific isoform of the klotho protein boosts memory in middle-aged and older mice, suggests a study in the October 31 Molecular Psychiatry. Scientists led by Miguel Chillón, Universitat Autònoma, Barcelona, Spain, reported that memory in aging wild-type mice held up better when they expressed a secreted isoform of the protein in ...
Relationship of Klotho with cognition and dementia: Results from …
Relationship of Klotho with cognition and dementia: Results from the NHANES 2011-2014 and Mendelian randomization study. Transl Psychiatry. 2023 Nov 1;13(1):337. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Orally-active, clinically-translatable senolytics restore α-Klotho in ...
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. EBioMedicine. 2022 Mar;77:103912. Epub 2022 Mar 13 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Impact of APOE, Klotho, and sex on cognitive decline with aging ...
2025年2月5日 · Impact of APOE, Klotho, and sex on cognitive decline with aging. Proc Natl Acad Sci U S A. 2025 Feb 11;122(6):e2416042122. Epub 2025 Feb 4 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.
Identification of the enzymatic cleavage relationship between anti ...
Identification of the enzymatic cleavage relationship between anti-aging protein α-Klotho and Alzheimer's disease biomarker BACE1. J Alzheimers Dis. 2025 Feb 24;:13872877251317730. Epub 2025 Feb 24 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.