2019年12月4日 · 该成果以题为 “The design and biomedical applications of self-assembled two-dimensional organic biomaterials” 发表在国际著名期刊 Chem. Soc. Rev.上。 Figure 1. 在溶液中形成2DOBM. (c,d)KLVFFAK纳米片的结构模型。 (b)立式纳米颗粒超晶格片的示意图。 （f）纳米组件的SEM图像。 （b）EF（电场）正增长的示意图。 （c）以琼脂糖水凝胶为印章的接触印刷技术，将合成后的自由漂浮纳米膜沉积在水敏性基材上。 Figure 8. DNA自组装形成2DOBM. …

A transmission electron microscopy (TEM) image of one of the supramolecular structures revealed a quadruple helix, which was previously very scarcely described. Interestingly, after a 5-min irradiation of PA1, the helical structures disappeared completely in the TEM images, and only cylindrical fibrils with a diameter of 11 nm were observed.

2022年3月1日 · KLVFFAK is a mutation of KLVFFAE Aβ (16–22). When the second phenylalanine in the KLVFFAK peptide is replaced with glycine (KLVFGAK), π-π stacking is much weaker than that of KLVFFAK. Therefore, the driving force for lateral growth is significantly weakened, and the self-assembly changes from a wider ribbon structure to a narrower ...

2015年3月3日 · We showed that KLVFFAK, a key amyloid-forming heptapeptide of the Italian familial form of Alzheimer’s Aβ , self-assembles into a 2D nanosheet with a width of over 200 nm, far larger than typical fibrils (10–20 nm) (Fig. 1). We characterized the molecular structure of the nanosheet with both biophysical and computational approaches.

2018年12月1日 · Mutated Aβ16-22 (KLVFFAK) is a fragment of β-amyloid peptide (Aβ42) from an Italian familial mutation type (Fig. 5 a). Mutated Aβ16-22 has been found to form giant sheets when incubated at a concentration of 4 mg/mL in 50 mM sodium phosphate buffer at pH 2 as well as at various concentrations of NaCl and MgCl 2 at 37 °C with incubation ...

Characterization of the KLVFFAK Nanosheet. We found that Italian familial Aβ16–22 (KLVFFAK) forms giant sheets in aqueous solution, distinct from typical long and unbranched fibrils formed by most amyloid-forming sequences (Fig. 1 B and C). The nano-sheet exhibits a cross-β diffraction pattern from X-ray diffraction

Download scientific diagram | a Sketch of virus particles attaching on nanosheets. b TEM images of virus particles attaching on KLVFFAK and KLVFFAR nanosheets. Reproduced with permission from...

The peptide with the sequence KLVFFAK is selected to modify the Ti 3 C 2 surface for this aim. The peptide sequence KLVFFAK is derived from a partial fragment of β-amyloid and is able to form nanosheets of moderate thickness and size through π–π interactions [26,27,28].

在这里，我们报告了一种基于磁性纳米粒子 (MNP) 的新型 KLVFF 修饰纳米磁体，其覆盖有非离子两亲性 β-环糊精 (SC16OH)，并装饰有 KLVFF 寡肽，用于自我识别 Aβ 的同源氨基酸序列从水样中收集 Aβ (1–42) 肽。 MNP@SC16OH 和 MNP@SC16OH/Ada-Pep 纳米组件通过互补技术作为固体粉末和水分散体得到了充分表征。 通过 TEM 分析观察到 20-40 nm 的单域 MNP@SC16OH/Ada-Pep 纳米磁体。

2016年9月28日 · The most thoroughly characterized peptide system, KLVFFAK, derives from the E22K mutant associated with the Italian familial form of the Aβ sequence. This peptide self-assembles into persistent nanosheets from acidic phosphate buffer (pH 2.0).