2024年3月8日 · The outer kinetochore is made up of the central and evolutionarily conserved ten-subunit KMN network complex, comprising the MIS12 (Mis12, Dsn1, Nsl1, Pmf1), NDC80 …

2024年3月8日 · Kinetochores, large layered structures built on specialized chromosome loci named centromeres, promote biorientation by binding and sensing spindle microtubules. One …

Reports the biochemical reconstitution of the KMN network and identifies two microtubule-binding activities within it: one in the NDC80–NUF2 dimer of the Ndc80 complex and the second in KNL1.

The highly conserved KMN network includes the Knl1 complex, which in vertebrates consists of KNL1 (also known as CASC5 or blinkin in humans, Spc105 in yeast and Spc105R in fly) and …

kmn 高度伸长，并通过其相反极端的界面停靠在动粒和微管上。 在这里，我们结合低温电子显微镜重建和 AlphaFold2 预测来生成人类 KMN 模型，该模型揭示了所有 KMN 内部界面。

The KMN is highly elongated and docks on kinetochores and microtubules through interfaces at its opposite extremes. Here, we combine cryogenic electron microscopy reconstructions and …

Here, we combine cryogenic electron microscopy reconstructions and AlphaFold2 predictions to generate a model of the human KMN that reveals all intra-KMN interfaces. We identify and …

The outer kinetochore is made up of the central and evolutionarily conserved ten-subunit KMN network complex, comprising the MIS12 (Mis12, Dsn1, Nsl1, Pmf1), NDC80 (Ndc80, Nuf2, …

2024年5月20日 · The KMN (Knl1/Mis12/Ndc80) network at the kinetochore, primarily known for its role in chromosome segregation, has been shown to be repurposed during neurodevelopment. …

2012年12月15日 · The highly conserved KMN network includes the Knl1 complex, which in vertebrates consists of KNL1 (also known as CASC5 or blinkin in humans, Spc105 in yeast …