Histone-lysine N-methyltransferase 2A, also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX), is an …

KMT2A encodes a lysine methyltransferase (KMT) formed of 3969 amino acids, a transcriptional co-activator which plays a crucial role in hematopoiesis, in regulating gene expression at early …

2024年12月25日 · KMT2A (Lysine Methyltransferase 2A) is a Protein Coding gene. Diseases associated with KMT2A include Wiedemann-Steiner Syndrome and Acute Myeloid Leukemia …

KMT2A (alias: mixed-lineage leukemia [MLL]) gene mapping on chromosome 11q23 encodes the lysine-specific histone N-methyltransferase 2A and promotes transcription by inducing an …

2024年4月27日 · This document includes details about the KMT2A gene and all yet known partner genes of direct KMT2A fusion alleles (n = 112) or KMT2A::PTDs.

The KMT2A (formerly MLL) encodes the histone lysine-specific N-methyltransferase 2A and is mapped on chromosome 11q23. KMT2A is a frequent target for recurrent translocations in …

Lysine-specific methyl transferase 2A (KMT2A), also known as MLL1, is a promiscuous gene with over 80 different gene-fusion partners [67]. KMT2A rearrangements (KMT2A-r) are detected in …

2024年11月5日 · The KMT2A (lysine methyltransferase 2A) regulates hematopoiesis, cellular development, and gene expression. KMT2A mutations including genetic rearrangements (re …

KMT2A is targeted by miR-361-3p and modulates leukemia cell's abilities to proliferate, migrate and invade. The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies …

2021年11月5日 · KMT2A partial tandem duplication (KMT2A -PTD), characterized by a large internal duplication spanning 6-8 exons, has been documented in adult AML with a prevalence …

2022年3月15日 · KMT2A (Lysine methyltransferase 2A) is a member of the epigenetic machinery, encoding a lysine methyltransferase responsible for the transcriptional activation through …

2023年11月2日 · KMT2A -PTD (also called MLL -PTD, partial tandem duplication), a non-fusion gene rearrangement, also occurs and serves as an important biomarker for Menin-inhibitors. …

2024年11月5日 · KMT2A rearrangements (KMT2Ar) in leukemia can involve fusion with other genes or partial tandem duplication (KMT2A-PTD). A small number of patients may present …

2024年8月20日 · KMT2A (alias: mixed-lineage leukemia [MLL]) gene mapping on chromosome 11q23 encodes the lysine-specific histone N-methyltransferase 2A and promotes transcription …

6 天之前 · KMT2A-rearranged (KMT2A-R) ALL is a high-risk disease associated with frequent chemoresistance and poor clinical outcomes in most patients with a survival rate of <75% in …

5 天之前 · Wiedemann-Steiner syndrome (WSS) is a congenital malformation syndrome characterized by intellectual disability, developmental delay, and distinctive facial features, …

2022年3月15日 · KMT2A (Lysine methyltransferase 2A), also known as MLL1, is a protein coding gene mapping to human chromosome 11 (11q23.3), made up of 90,343 bases …

2021年11月5日 · Genetic rearrangements involving the KMT2A gene (KMT2A -R) are seen in around 10% of acute leukemia overall. KMT2A -R occurs in all ages and usually correlates …

FISH was performed using probes for common gene-fusions: BCR-ABL1, ETV6-RUNX1, KMT2A-AFF1, TCF3- HLF. 850 K CytoSNP data was analyzed using BlueFuse Multi v4.5. CNA results …