Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono …

2024年12月25日 · KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Diseases associated with KMT2D include Kabuki Syndrome 1 and Branchial Arch Abnormalities, …

2-DG（和程度较小的POMHEX，KA和vorinostat）比KMT2D-WT细胞系更大程度地抑制了KMT2D突变细胞系的融合。KMT2D突变后，肿瘤体积明显增大，但使用2-DG后肿瘤体积显著 …

Notably, the histone lysine methyltransferase KMT2D (a COMPASS/ Set1 family member; also known as MLL4, ALR, and MLL2) is among the most frequently mutated genes in many …

KMT2D is a major mammalian H3K4 mono-methyltransferase and co-localizes with lineage determining transcription factors on transcriptional enhancers. It is required for the binding of …

2023年1月9日 · Combining SHP2 inhibitor SHP099 and pan-ERBB inhibitor afatinib inhibits lung tumor growth in Kmt2d-deficient LUSC murine models and in patient-derived xenografts …

The KMT2D gene, also known as MLL2 , provides instructions for making an enzyme called lysine-specific methyltransferase 2D that is found in many organs and tissues of the body. …

KMT2D epigenetically activates PI3K/Akt pathway and epithelial-mesenchymal transition by targeting LIFR and KLF4 and thus serves as a putative epigenetic-based target for treating …

2017年12月22日 · Histone lysine methyltransferase 2D (KMT2D/MLL2), an important epigenetic modifier that catalyzes the monomethylation of H3K4 (H3K4me1) [11], has been found to be …

编码的蛋白质是称为 ASCOM 的大型蛋白质复合体的一部分，已被证明是 β-珠蛋白和雌激素受体基因的转录调节剂。 该基因的突变已被证明是歌舞伎综合症的一个原因。 [RefSeq 提供，2010 …